Table 4

Mixed effects logistic models for each first-line empirical treatment category

Fixed effectsTriple-C+ATriple-C+MSequential-C+A+T/M
95% CI95% CI95% CI
ORLowerUpperP valueORLowerUpperP valueORLowerUpperP value
Age-centred1.0051.0011.0100.0450.9920.9801.0050.2451.0131.0011.0260.049
Sex1.1560.9931.3510.0611.1870.7881.7890.4131.9771.2923.0260.002
Diagnosis1.3541.0931.6770.0061.7300.9353.1990.0811.3890.5573.4660.481
Length
 7 days11
 10 days1.45211.1251.8750.0020.5640.2491.2810.1721
 14 days1.5471.1092.1590.0100.6650.2551.7370.406
PPI dose OE†
 Low111
 Standard1.4491.1681.7880.0013.6801.35210.0200.0113.1930.83112.7290.091
 High1.6341.2512.135<0.0011.8061.0803.0190.0241.8321.1133.0140.017
Compliance7.5764.49712.765<0.00141.4792.022850.790.01622.2417.31067.670<0.001
Constant0.5460.3060.9760.0410.0660.0031.2400.0770.1860.0560.6120.006
Random effectsEstim.SEEstim.SEEstim.SE
Variance0.7880.189<0.0011.5410.852<0.0010.6330.362<0.001
ICC0.1930.3120.161
Fixed effectsConcomitant-C+A+ T/MSingle capsule bismuth quadruple*Quadruple-C+A+B
95% CI95% CI95% CI
ORLowerUpperP valueORLowerUpperP valueORLowerUpperP value
Age-centred0.9940.9880.9990.0391.0010.9871.0170.8250.9960.9841.0080.502
Sex1.3651.0751.7350.0110.6090.3581.0360.0551.0050.6941.4570.977
Diagnosis1.5001.0372.1610.0311.7060.6784.2940.2121.5460.8932.6760.120
Length
 7 days1
 10 days0.4600.0553.8310.47311
 14 days0.5360.0644.4990.5661.9130.9993.6610.051
PPI dose OE†
 Low111
 Standard1.6621.1272.4520.0101.1910.5632.5170.6482.1511.0774.2940.027
 High1.6991.1922.4210.0031.1320.5652.2680.7261.3770.6772.8030.296
Compliance4.5862.6407.964<0.00124.9199.74263.744<0.00148.8731.51415.5050.007
Constant3.5490.40631.003 0.2521.0160.3812.7090.9751.0580.3043.6750.929
Random effectsEstim.SEEstim.SEEstim.SE
Variance0.3120.138<0.0010.3700.2980.0150.3280.219<0.002
ICC0.0870.1010.091
  • *Three-in-one single capsule containing bismuth, tetracycline and metronidazole.

  • †Comparison between standard dose PPI (reference) and high dose PPI were performed and no statistically significant differences were found in any of the treatment categories.

  • A, amoxicillin; B, bismuth salts; C, clarithromycin; Estim, Estimate; ICC, intraclass correlation coefficient; ITT, intention-to-treat; L, levofloxacin; M, metronidazole; mITT, modified intention-to-treat; NA, Not applicable; OE, omeprazole equivalent; PP, per protocol; PPI, proton pump inhibitor; Tc, tetracycline.