Outcome of postprandial combined HRM and pH-impedance monitoring of treated achalasia patients with (RS+) and without reflux symptoms (RS−)
| Patients with reflux symptoms (RS+) | Patients without reflux symptoms (RS−) | P value | |
| (n=19) | (n=19) | ||
| Postprandial combined HRM and pH-impedance measurement | |||
| Presence acid exposure (n (%)) | 5/19 (26) | 2/19 (11) | 0.41 |
| Acid exposure time (AET: % of time pH <4; mean (95% CI) | 1.9 (−1.06 to 4.85) | 2.6 (−2.67 to 7.87) | 0.81 |
| Acidification patterns (% of time; mean (95% CI)) | |||
| Acid reflux with normal clearance | 0.3 (−0.06 to 0.78) | 0 (0 to 0) | 0.09 |
| Acid reflux with delayed clearance | 1.4 (−1.48 to 4.18) | 2.5 (−2.78 to 7.80) | 0.69 |
| Acid fermentation | 0 (0 to 0) | 0 (0 to 0) | 1 |
| Stasis of ingested acidic food | 0 (0 to 0) | 0 (0 to 0) | 1 |
| Unclassified | 0.2 (−0.21 to 0.60) | 0 (0 to 0) | 0.53 |
| No of acidification events (median (IQR)) | |||
| Acid reflux with normal clearance | 0 (0–2) | 0 (0–0) | 0.04 |
| Acid reflux with delayed clearance | 0 (0–1) | 0 (0–1) | 0.97 |
| Acid fermentation | 0 (0–0) | 0 (0–0) | 1 |
| Stasis of ingested acidic food | 0 (0–0) | 0 (0–0) | 1 |
| Unclassified | 0 (0–1) | 0 (0–1) | 0.32 |
| No of patients per acidification pattern (n (%)) | |||
| Acid reflux with normal clearance | 4 (21) | 0 (0) | 0.04 |
| Acid reflux with delayed clearance | 1 (5) | 1 (5) | 1 |
| Acid fermentation | 0 (0) | 0 (0) | 1 |
| Stasis of ingested acidic food | 0 (0) | 0 (0) | 1 |
| Unclassified | 1 (5) | 0 (0) | 0.32 |
| No of symptoms (median (IQR)) | 0 (0–1) | 0 (0–0) | 0.02 |
AET, acid exposure time; HRM, high-resolution manometry.