Table 2

Associations between 18-month intrahepatic fat change and 18-month anthropometric parameters and blood biomarkers changes

Model 1Model 2Model 3
Beta coefficientP valueBeta coefficientP valueBeta coefficientP value
∆Waist circumference0.563.7e-19
∆Systolic BP0.
∆Diastolic BP0.281.9e-50.160.0050.110.04
Glycaemic biomarkers
∆HOMA IR0.268.8e-
Lipid biomarkers
∆TG/HDL ratio0.403.3E-100.252.0e-50.140.02
∆Cholesterol/HDL ratio0.362.6e-80.241.4e-50.150.007
Liver enzymes and hepatokines
∆ALT/AST ratio0.366.2e-80.239.8e-50.100.069
Adipokines and inflammation
  • Model 1: adjusted for age, sex, baseline IHF% and intervention group.

  • Model 2: adjusted for age, sex, baseline IHF% intervention group, and 18-month waist circumference change.

  • Model 3: adjusted for age, sex, baseline IHF%, intervention group and 18-month weight change.

  • ALKP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate transaminase; BP, blood pressure; FGF, fibroblast growth factor; HDL, high-density lipoprotein; HOMA IR, homeostatic model assessment of insulin resistance; hsCRP, high sensitivity C reactive protein; LDL, low-density lipoprotein; TG, triglycerides.