Univariate and multivariable analysis by logistic regression on factors associated with ALT and/or AST elevation in patients infected by SARS-CoV-2
| Parameters | Univariate analysis | Multivariable analysis | ||
| OR (95% CI) | P value | aOR (95% CI) | P value | |
| Use of antiviral agents | ||||
| No use of antiviral agents | Referent | Referent | ||
| Lopinavir–ritonavir ±ribavirin | 1.35 (0.83 to 2.19) | 0.225 | 1.10 (0.66 to 1.82) | 0.722 |
| Lopinavir–ritonavir ±ribavirin + interferon beta | 2.45 (1.55 to 3.86) | <0.001 | 1.94 (1.20 to 3.13) | 0.006 |
| Use of corticosteroid | 6.98 (4.00 to 12.19) | <0.001 | 3.92 (2.14 to 7.16) | <0.001 |
| Age | 1.03 (1.02 to 1.04) | <0.001 | 1.02 (1.01 to 1.03) | <0.001 |
| Male gender | 2.55 (1.79 to 3.62) | <0.001 | 2.49 (1.72 to 3.60) | <0.001 |
| Diabetes mellitus | 3.39 (2.08 to 5.50) | <0.001 | ||
| Hypertension | 2.68 (1.80 to 4.00) | <0.001 | ||
ALT and/or AST elevation was defined by ALT and/or AST≥2 × ULN at baseline or during follow-up. The ULN of ALT and AST were 40 U/L.
P value=0.235 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.
ALT, alanine aminotransferase; aOR, adjusted OR; AST, aspartate aminotransferase; CoV, coronavirus; SARS, severe acute respiratory syndrome; ULN, upper limit of normal.