Table 4

Univariate and multivariable analysis by logistic regression on factors associated with primary end point (a composite end point of admission to intensive care unit, use of invasive mechanical ventilation and death) in patients infected by SARS-CoV-2

ParametersUnivariate analysisMultivariable analysis*
OR (95% CI)P valueaOR (95% CI)P value
Peak ALT and/or AST≥2×ULN10.36 (5.63 to 19.05)<0.0017.92 (4.14 to 15.14)<0.001
Age1.05 (1.03 to 1.07)<0.001
Male gender1.75 (0.98 to 3.10)0.057
Diabetes mellitus11.60 (6.35 to 21.18)<0.0014.14 (1.96 to 8.71)<0.001
Hypertension6.16 (3.49 to 10.87)<0.0012.28 (1.14 to 4.54)0.020
Lymphocyte <1×109/L2.89 (1.66 to 5.03)<0.001
Platelet0.995 (0.990 to 0.999)0.018
Albumin0.87 (0.82 to 0.91)<0.0010.92 (0.87 to 0.98)0.005
Creatinine1.02 (1.01 to 1.03)0.002
ParametersUnivariate analysisMultivariable analysis†
OR (95% CI)P valueaOR (95% CI)P value
ALT and/or AST≥2 ×ULN with total bilirubin ≥2 ×ULN and/or INR ≥1.718.33 (6.48 to 52.73)<0.0016.40 (1.78 to 23.07)0.005
Age1.05 (1.03 to 1.07)<0.001
Male gender1.75 (0.98 to 3.10)0.057
Diabetes mellitus11.60 (6.35 to 21.18)<0.0014.63 (2.21 to 9.72)<0.001
Hypertension6.16 (3.49 to 10.87)<0.0012.20 (1.08 to 4.48)0.031
Lymphocyte <1×109/L2.89 (1.66 to 5.03)<0.0011.97 (1.05 to 3.69)0.035
Platelet0.995 (0.990 to 0.999)0.018
Albumin0.87 (0.82 to 0.91)<0.0010.94 (0.88 to 0.99)0.027
Creatinine1.02 (1.01 to 1.03)0.002
  • The ULN of ALT and AST were 40 U/L. The ULN of total bilirubin was 19 µmol/L.

  • *P value = 0.736 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.

  • † P value =0.105 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.

  • ALT, alanine aminotransferase; aOR, adjusted OR; AST, aspartate aminotransferase; CoV, coronavirus; INR, international normalised ratio; SARS, severe acute respiratory syndrome; ULN, upper limit of normal.