Univariate and multivariable analysis by logistic regression on factors associated with primary end point (a composite end point of admission to intensive care unit, use of invasive mechanical ventilation and death) in patients infected by SARS-CoV-2
Parameters | Univariate analysis | Multivariable analysis* | ||
OR (95% CI) | P value | aOR (95% CI) | P value | |
Peak ALT and/or AST≥2×ULN | 10.36 (5.63 to 19.05) | <0.001 | 7.92 (4.14 to 15.14) | <0.001 |
Age | 1.05 (1.03 to 1.07) | <0.001 | ||
Male gender | 1.75 (0.98 to 3.10) | 0.057 | ||
Diabetes mellitus | 11.60 (6.35 to 21.18) | <0.001 | 4.14 (1.96 to 8.71) | <0.001 |
Hypertension | 6.16 (3.49 to 10.87) | <0.001 | 2.28 (1.14 to 4.54) | 0.020 |
Lymphocyte <1×109/L | 2.89 (1.66 to 5.03) | <0.001 | ||
Platelet | 0.995 (0.990 to 0.999) | 0.018 | ||
Albumin | 0.87 (0.82 to 0.91) | <0.001 | 0.92 (0.87 to 0.98) | 0.005 |
Creatinine | 1.02 (1.01 to 1.03) | 0.002 |
Parameters | Univariate analysis | Multivariable analysis† | ||
OR (95% CI) | P value | aOR (95% CI) | P value | |
ALT and/or AST≥2 ×ULN with total bilirubin ≥2 ×ULN and/or INR ≥1.7 | 18.33 (6.48 to 52.73) | <0.001 | 6.40 (1.78 to 23.07) | 0.005 |
Age | 1.05 (1.03 to 1.07) | <0.001 | ||
Male gender | 1.75 (0.98 to 3.10) | 0.057 | ||
Diabetes mellitus | 11.60 (6.35 to 21.18) | <0.001 | 4.63 (2.21 to 9.72) | <0.001 |
Hypertension | 6.16 (3.49 to 10.87) | <0.001 | 2.20 (1.08 to 4.48) | 0.031 |
Lymphocyte <1×109/L | 2.89 (1.66 to 5.03) | <0.001 | 1.97 (1.05 to 3.69) | 0.035 |
Platelet | 0.995 (0.990 to 0.999) | 0.018 | ||
Albumin | 0.87 (0.82 to 0.91) | <0.001 | 0.94 (0.88 to 0.99) | 0.027 |
Creatinine | 1.02 (1.01 to 1.03) | 0.002 |
The ULN of ALT and AST were 40 U/L. The ULN of total bilirubin was 19 µmol/L.
*P value = 0.736 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.
† P value =0.105 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.
ALT, alanine aminotransferase; aOR, adjusted OR; AST, aspartate aminotransferase; CoV, coronavirus; INR, international normalised ratio; SARS, severe acute respiratory syndrome; ULN, upper limit of normal.