Table 4

Univariate and multivariable analysis by logistic regression on factors associated with primary end point (a composite end point of admission to intensive care unit, use of invasive mechanical ventilation and death) in patients infected by SARS-CoV-2

Parameters	Univariate analysis		Multivariable analysis*
Parameters	OR (95% CI)	P value	aOR (95% CI)	P value
Peak ALT and/or AST≥2×ULN	10.36 (5.63 to 19.05)	<0.001	7.92 (4.14 to 15.14)	<0.001
Age	1.05 (1.03 to 1.07)	<0.001
Male gender	1.75 (0.98 to 3.10)	0.057
Diabetes mellitus	11.60 (6.35 to 21.18)	<0.001	4.14 (1.96 to 8.71)	<0.001
Hypertension	6.16 (3.49 to 10.87)	<0.001	2.28 (1.14 to 4.54)	0.020
Lymphocyte <1×10⁹/L	2.89 (1.66 to 5.03)	<0.001
Platelet	0.995 (0.990 to 0.999)	0.018
Albumin	0.87 (0.82 to 0.91)	<0.001	0.92 (0.87 to 0.98)	0.005
Creatinine	1.02 (1.01 to 1.03)	0.002

Parameters	Univariate analysis		Multivariable analysis†
Parameters	OR (95% CI)	P value	aOR (95% CI)	P value
ALT and/or AST≥2 ×ULN with total bilirubin ≥2 ×ULN and/or INR ≥1.7	18.33 (6.48 to 52.73)	<0.001	6.40 (1.78 to 23.07)	0.005
Age	1.05 (1.03 to 1.07)	<0.001
Male gender	1.75 (0.98 to 3.10)	0.057
Diabetes mellitus	11.60 (6.35 to 21.18)	<0.001	4.63 (2.21 to 9.72)	<0.001
Hypertension	6.16 (3.49 to 10.87)	<0.001	2.20 (1.08 to 4.48)	0.031
Lymphocyte <1×10⁹/L	2.89 (1.66 to 5.03)	<0.001	1.97 (1.05 to 3.69)	0.035
Platelet	0.995 (0.990 to 0.999)	0.018
Albumin	0.87 (0.82 to 0.91)	<0.001	0.94 (0.88 to 0.99)	0.027
Creatinine	1.02 (1.01 to 1.03)	0.002

The ULN of ALT and AST were 40 U/L. The ULN of total bilirubin was 19 µmol/L.
*P value = 0.736 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.
† P value =0.105 for Hosmer-Lemeshow goodness-of-fit test, which did not indicate significant poor fit.
ALT, alanine aminotransferase; aOR, adjusted OR; AST, aspartate aminotransferase; CoV, coronavirus; INR, international normalised ratio; SARS, severe acute respiratory syndrome; ULN, upper limit of normal.