Table 1

Baseline characteristics, stratified by genetic risk category




Mutation carriers
(n=165)
FPC kindreds
(n=201)
P value
Age, mean (SD), years52 (9.6)56 (9.8)<0.001
Male sex, n (%)73 (44)84 (42)0.64
BMI, median (IQR)25 (4.5)25 (5)0.46
Gene mutation, n (%)
CDKN2A p1696 (58)
BRCA2 + ≥2 blood relatives with PDAC45 (27)
  BRCA2 + ≥1 FDR with PDAC25
  BRCA2 + ≥1 SDR with PDAC but no FDR with PDAC9
  BRCA2 without FDR or SDR with PDAC11
BRCA1 + ≥2 blood relatives with PDAC7 (4)
  BRCA1 + ≥1 FDR with PDAC6
  BRCA1 + ≥1 SDR with PDAC but no FDR with PDAC1
PALB2 + 3 blood relatives with PDAC2 (1)
STK11/LKB19 (6)
TP53 + 2 blood relatives with PDAC5 (3)
  TP53 + ≥1 FDR with PDAC2
  TP53 + ≥1 SDR with PDAC but no FDR with PDAC3
ATM + 3 FDR with PDAC1 (1)
Total number of any degree blood relatives with PDAC, n (%)<0.001
 032 (19)
 124 (15)
 249 (30)104 (52)
 3 or more56 (34)96 (48)
Age youngest blood relative with PDAC, median (IQR), years49 (16)56 (15)<0.001
Blood relative with PDAC <50 years of age, n (%)65 (39)58 (29)<0.001
Personal history of non-pancreatic malignancy, n (%)81 (49)24 (12)<0.001
Personal history of diabetes mellitus, n (%)3 (2)13 (7)0.03
Personal history of acute pancreatitis, n (%)0 (0)7 (4)0.02
Smoking, n (%)0.32
 Never78 (47)101 (50)
 Former68 (41)67 (33)
 Current17 (10)31 (15)
Alcohol use, n (%)0.88
 Never39 (24)42 (21)
 Former7 (4)11 (6)
 Current116 (70)145 (72)
  • By definition, FPC kindreds do not carry any of the known PDAC susceptibility gene mutations and have two or more blood relatives affected with PDAC. For the total number of blood relatives with PDAC, smoking and alcohol use, percentages may not add up to 100% because of missing data in up to 2% of participants.

  • FDR, first-degree blood relative; FPC, familial pancreatic cancer; PDAC, pancreatic ductal adenocarcinoma; SDR, second-degree blood relative.