Table 3

Predictors for the development of pancreatic cancer in univariable analysis

VariablesPDAC
(n=10)
No PDAC
(n=356)
P value
Patient characteristics
 Age, median (IQR)57 (16)54 (13)0.75
 Mutation carrier, n (%)10 (100)155 (44)<0.001
 History of non-pancreatic malignancy, n (%)5 (50)100 (28)0.16
 History of diabetes mellitus, n (%)1 (10)15 (4)0.36
 Smoking, n (%)3 (30)45 (13)0.37
Family characteristics
 Total number of blood relatives with PDAC, median (IQR)2 (3)2 (1)0.83
 Blood relative with PDAC<50 years of age, n (%)3 (30)120 (34)>0.99
Pancreatic abnormalities on imaging
 Solid lesion, n (%)7 (70)14 (4)<0.001
 Indeterminate lesion*, n (%)1 (10)33 (9)>0.99
 Cystic lesion, n (%)5 (50)188 (53)>0.99
 Cystic lesion with solid component or mural nodule, n (%)2 (20)3 (1)0.006
 Cystic lesion with growth speed>5 mm/year, n (%)3 (30)22 (6)0.03
 Main pancreatic duct 5–9 mm (with or without focal lesion), n (%)4 (40)17 (5)0.001
  • Patient and family characteristics were assessed at baseline, pancreatic abnormalities scored if present at any visit.

  • *Hypoechoic or hypointense lesions of unknown significance that could not with certainty be classified as solid or cystic at diagnosis.

  • PDAC, pancreatic ductal adenocarcinoma.