Table 1

The enriched microbes in the oral cavity, gut and tumours in murine models and human samples

HostStudy groupEnriched bacteriaReference
Oral microbiota
HumanPrediagnostic samples, PDAC versus matched controlsPorphyromonas gingivalis, Aggregatibacter actinomycetemcomitansFan et al20
HumanPDAC versus healthy controlsNeisseria elongate, Streptococcus mitisFarrell et al21
Gut microbiota
HumanPDAC versus healthy controlsPrevotella, Veillonella, Klebsiella, Selenomonas, Hallella, Enterobacter, CronobacterRen et al18
HumanPDAC versus healthy controlsBacteroidetes, Veillonellaceae, Akkermansia, OdoribacterHalf et al22
HumanPDAC versus healthy controlsProteobacteria, Synergistetes, EuryarchaeotaPushalkar et al23
MousePDAC spontaneous modelActinobacteria, Deferribacteres, Bifidobacterium pseudolongum
MousePDAC subcutaneous modelBacteroidetes, FirmicutesSethi et al48
MousePDAC spontaneous modelBacteroides, AlphaproteobacteriaMendez et al26
Tumour microbiota
HumanPDAC versus healthy controlsGammaproteobacteriaGeller et al37
HumanPDAC tumour versus gutProteobacteria (Pseudomonas, Elizabethkingia)Pushalkar et al23
HumanPDACAcinetobacter, Afipia, Corynebacterium, Escherichia, PropionibacteriumThomas et al27
HumanPDACGammaproteobacteria, Bacilli, ActinobacteriaRiquelme et al40
HumanPDAC long-term survivors versus short-term survivorsPseudoxanthomonas, Streptomyces, Saccharopolyspora, Bacillus clausii
Cyst microbiota
HumanIPMN, MCN, SCA, pseudocystsBacteroides, Escherichia/Shigella, Fusobacterium, Acidaminococcus, Sphingomonas, BifidobacteriumLi et al35
HumanCancerous versus non-cancerous PCNsFusobacterium nucleatum, Granulicatella adiacensGaiser et al36
  • IPMN, intraductal papillary mucinous neoplasm; MCN, mucinous cystic neoplasm; PCN, pancreatic cystic neoplasias; PDAC, pancreatic ductal adenocarcinoma; SCA, serous cystadenoma.