Table 2

Univariate and multivariate survival analysis in Pac-UFT

Factors	Univariate		Multivariate
N=123	HR (95% CI)	P value	HR (95% CI)	P value
Random forest gene signature Pac-Sensitive versus Pac-Resistant	0.44 (0.25 to 0.76)	0.0038	0.42 (0.24 to 0.76)	0.0037
Age	1.00 (0.97 to 1.03)	0.79	0.99 (0.96 to 1.03)	0.70
Gender: Female versus male	0.70 (0.38 to 1.28)	0.25	0.57 (0.30 to 1.09)	0.09
ECOG Performance Status: PS 1 versus PS 0	1∙27 (0.66 to 2.47)	0.47	1.43 (0.70 to 2.91)	0.33
Histology Undifferentiated/others versus differentiated	1.43 (0.81 to 2.51)	0.22	1.55 (0.85 to 2.81)	0.15
Depth of invasion pT3/4 vs pT1/2	2.48 (1.17 to 5.26)	0.018	2∙43 (1.12 to 5.26)	0.024
Lymph node status pN2/3 vs pN0/1	2.89 (1.69 to 4.94)	<0.001	2∙56 (1.47 to 4.48)	<0.001