Table 1

Personal and family GC history in index cases assessed for germline variants in the APC promoter 1B

Personal cancer history	No of index cases	Family history of GC, no of index cases*
Personal cancer history	No of index cases	HDGC	FIGC	Any GC	None
Personal history of GC†	199	149	1	16	33
Other cancer history‡
Obligate carrier	2	2	0	0	0
Non-obligate carrier	38	12	0	26	0
Unaffected
Obligate carrier	4	4	0	0	0
Non-obligate carrier	16	7	0	9	0
Total	259	174	1	51	33

*Family history of GC in first-degree and second-degree relatives.
†Index case GC subtypes: diffuse GC (n=170), intestinal GC (n=10), mixed (n=4), not otherwise specified (n=15).
‡Other cancer types: breast (n=31), colon (n=4), ovarian (n=1), prostate (n=2), skin (n=2), thymoma (n=1), uterine (n=1). Two index cases were affected by more than one cancer type.
DGC, diffuse gastric cancer; FIGC, familial intestinal gastric cancer; GC, gastric cancer; HDGC, hereditary diffuse gastric cancer; IGC, intestinal gastric cancer.