Types of obstetric complications (n=1000)
| Controls (n=564) | Anti-TNF-α monotherapy (n=136) | P value | Thiopurine monotherapy (n=240) | P value | Anti-TNF-α and thiopurine (n=60) | P value | |
| Hyperemesis gravidarum (%) | 5 (1) | 0 (0) | 0.59 | 2 (1) | 1.00 | 0 (0) | 1.00 |
| Intrahepatic cholestasis of pregnancy (ICP) (%) | 3 (1) | 1 (1) | 0.58 | 9 (4) | <0.01 | 3 (5) | 0.01 |
| In utero growth restriction (%) | 2 (1) | 2 (1) | 0.17 | 2 (1) | 0.59 | 0 (0) | 1.00 |
| Hypertension/pre-eclampsia (%) | 28 (5) | 6 (4) | 1.00 | 13 (5) | 0.86 | 7 (13) | 0.07 |
| HELLP (%) | 4 (1) | 1 (1) | 1.00 | 2 (1) | 1.00 | 2 (3) | 0.11 |
| Gestational diabetes (%) | 16 (3) | 5 (3) | 0.58 | 4 (1) | 0.46 | 1 (1) | 1.00 |
Study groups were compared with the controls. The Bonferroni correction was applied to adjust for multiple testing. A statistically significant difference was defined as a P < 0.02.
HELLP, haemolysis, elevated liver enzyme levels and low platelet levels; TNF, tumour necrosis factor.