Weight loss outcomes over time, up to 1-year post-E-ESG in both groups (treatment performed at baseline (procedure) or after 6 months of dietary and lifestyle counselling (control))
| Baseline | 3 months | 6 months | 12 months | 18 months | |||||
| Procedure | Control | Procedure | Control | Procedure | Control | Procedure | Control | Control | |
| N | 49 | 22 | 44 | 22 | 45 | 21 | 41 | 16 | 16 |
| Weight, mean | 93. 3 | 94. 7 | 84. 2 | 93. 5 | 82. 9 | 93. 0 | 81. 5 | 83. 5 | 83. 9 |
| 95% CI | (90.77 to 95.85) | (90.46 to 98.92) | (81.36 to 87.03) | (88.42 to 98.51) | (79.71 to 85.99) | (87.23 to 98.70) | (78.03 to 84.90) | (76.03 to 90.87) | (75.64 to 92.10) |
| BMI, mean | 34.8 | 34.2 | 31.6 | 33.7 | 31.2 | 33.4 | 31.0 | 29.7 | 30.1 |
| 95% CI | (34.00 to 35.53) | (33.04 to 35.26) | (30.83 to 32.41) | (32.20 to 35.22) | (30.33 to 32.06) | (31.62 to 35.14) | (29.89 to 32.02) | (27.85 to 31.58) | (27.77 to 32.35) |
| EWL (%), mean | – | – | 34.5 | 7.7 | 38.6 | 13.4 | 42.7 | 43.6 | 51.3 |
| 95% CI | (29.12 to 39.82) | (1.16 to 16.56) | (31.11 to 45.98) | (0.74 to 27.51) | (33.14 to 52.33) | (26.87 to 60.29) | (21.89 to 80.66) | ||
| TBWL (%), mean | – | – | 9.6 | 1.4 | 11.0 | 2.7 | 11.9 | 10.9 | 11.5 |
| 95% CI | (8.07 to 11.03) | (0.37 to 3.22) | (8.86 to 13.15) | (0.14 to 5.44) | (9.32 to 14.46) | (7.02 to 14.70) | (6.54 to 16.37) | ||
The weight loss 1 year after E-ESG corresponds to 12 months values in the procedure group and 18 months values in the control group, follow-up being calculated from randomisation.
Arrows show the time of the switch to E-ESG in the control group.
BMI, body mass index ; CI, confidence interval; E-ESG, endoscopic suture gastroplasty with the endomina; EWL, excess weight loss ; TBWL, total body weight loss.