Table 4

Absolute risk and Cox proportional hazards models for overall, sex-stratified and age-stratified analyses in haematochezia analytic cohort

Cohort characteristicsAbsolute estimatesCox proportional hazards models
Baseline
at risk (N)		Number of YCRC cases5-year cumulative incidence % (95% CI)Risk difference
% (95% CI)		NNS (95% CI)Unadjusted HR (95% CI)Adjusted HR (95% CI)
Overall Haematochezia130 7484060.33
(0.30–0.36)		0.30
(0.26–0.33)		322
(293.4–359.1)		10.88
(9.02–13.12)		10.66
(8.76–12.97)
No haematochezia522 9921500.03
(0.03–0.04)
Age <30 years Haematochezia19 70090.05
(0.02–0.08)		0.04
(0.01–0.08)		2188.9
(1312–4985)		12.02
(3.25–44.41)		16.47
(4.09–66.29)
No haematochezia78 87530.003
(0.00–0.01)
Ages 30–39 years Haematochezia32 506510.16
(0.12–0.20)		0.15
(0.11–0.19)		637.4
(497.4–865.6)		17.09
(9.11–32.05)		17.21
(8.88–33.35)
No haematochezia130 294120.01
(0.00–0.01)
Ages 40–49 years Haematochezia78 5423460.50
(0.44–0.55)		0.43
(0.38–0.49)		227
(206.3–253.3)		10.32
(8.45–12.59)		10.12
(8.22–12.45)
No haematochezia313 8231350.06
(0.05–0.07)
Men Haematochezia114 2593710.35
(0.31–0.38)		0.31
(0.27–0.35)		308
(280.3–342.9)		10.43
(8.60–12.65)		10.16
(8.30–12.44)
No haematochezia457 0361430.04
(0.03–0.04)
Men,
aged <30 years 		Haematochezia16 36760.04
(0.01–0.07)		0.03
(0.01–0.06)		2727.8
(1428.6–10 000)		8.02
(2.01–32.07)		10.24
(2.31–45.30)
No haematochezia65 57130.004
(0.00–0.01)
Men,
aged 30–39 years 		Haematochezia27 761400.14
(0.10–0.19)		0.14
(0.10–0.18)		694
(526.3–1000)		16.07
(8.04–32.13)		15.68
(7.56–32.52)
No haematochezia111 167100.01
(0.00–0.02)
Men,
aged 40–49 years 		Haematochezia70 1313250.52
(0.47–0.58)		0.46
(0.39–0.52)		215.8
(196.1–243.9)		10.07
(8.22–12.34)		9.85
(7.97–12.18)
No haematochezia280 2981300.07
(0.06–0.08)
Women Haematochezia16 489350.22
(0.15–0.30)		0.21
(0.14–0.29)		471.1
(350.2–686.1)		20.05
(8.91–45.13)		20.60
(8.84–48.00)
No haematochezia65 95670.01
(0.00–0.02)
Women,
aged <30 years 		Haematochezia333330.09
(0.03–100)		0.09
(0.00–0.21)		1111
(476.2, Und)
No haematochezia13 30400.00
(0–100)
Women,
aged 30–39 years 		Haematochezia4745110.23
(0.11–0.39)		0.22
(0.09–0.38)		431.4
(263.2–909.1)		22.22
(4.93–100.26)		25.35
(5.30–121.30)
No haematochezia19 12720.01
(0.00–0.03)
Women,
aged 40–49 years 		Haematochezia8411210.27
(0.16–0.39)		0.25
(0.14–0.37)		400.5
(263.2–666.7)		16.79
(6.33–44.53)		15.99
(5.81–44.05)
No haematochezia33 52550.02
(0.00–0.04)

  • Risk difference corresponds to difference between exposed and unexposed cumulative incidence results. Number needed to scope (NNS) is the inverse of the CRC prevalence among exposed individuals.

  • Absolute estimates derived from 5-year cumulative incidence curve models accounting for censoring with bootstrapped 95% CIs.

  • Unadjusted model includes matching strata variable as random intercept; adjusted model additionally adjusts for race/ethnicity, BMI, prevalent diabetes, smoking status and aspirin use.

  • Empty cells reflect having zero cases, limiting the ability to conduct stratified analyses.

  • .BMI, body mass index; CRC, colorectal cancer; Und, undefined; YCRC, young-onset colorectal cancer.