Table 3

Results from univariate and multivariate analyses of baseline predictors of mortality, from Cox proportional hazard regression models

VariableUnivariable modelsMultivariable model
HR (95% CI)P valueHR (95% CI)P value
Age (years)
 <501 ref
 50–641.028 (0.435 to 2.432)0.95
 ≥651.827 (0.694 to 4.808)0.22
Gender, male versus female1.072 (0.551 to 2.084)0.84
Indication for LT
 HCC1 ref
 Decompensated cirrhosis without HCC10.567 (1.444 to 77.327)0.020
 Other4.126 (0.429 to 39.682)0.22
Aetiology
 HBV, HCV or other cirrhosis1 ref
 Alcohol1.354 (0.677 to 2.709)0.39
 NASH1.195 (0.348 to 4.107)0.78
 Other non-cirrohsis1.095 (0.251 to 4.776)0.90
 Dyspnoea as presenting symptom4.087 (2.139 to 7.808)<0.0013.894 (2.018 to 7.514)<0.0001
 BMI≥30 vs BMI<300.860 (0.378 to 1.960)0.72
 Diabetes mellitus (yes vs no)1.426 (0.748 to 2.717)0.28
 Kidney function impairment with p-creatinine>2 mg/dL2.61 (1.142 to 5.972)0.023
Number of comorbidities
 01 ref
 10.689 (0.298 to 1.595)0.38
 20.831 (0.316 to 2.19)0.71
 3+2.071 (0.813 to 5.271)0.13
MELD class
 MELD<151 ref1 ref
 MELD 15–195.267 (1.746 to 15.888)0.0035.463 (1.808 to 16.5016)0.003
 MELD≥206.055 (2.048 to 17.906)0.0015.242 (1.768 to 15.545)0.003
  • BMI, Body Mass Index; HCC, hepatocellular carcinoma; LT, liver transplantation; MELD, Model for End-stage Liver Disease; ref, reference.