Variable | Univariable models | Multivariable model | ||
HR (95% CI) | P value | HR (95% CI) | P value | |
Age (years) | ||||
<50 | 1 ref | |||
50–64 | 1.028 (0.435 to 2.432) | 0.95 | ||
≥65 | 1.827 (0.694 to 4.808) | 0.22 | ||
Gender, male versus female | 1.072 (0.551 to 2.084) | 0.84 | ||
Indication for LT | ||||
HCC | 1 ref | |||
Decompensated cirrhosis without HCC | 10.567 (1.444 to 77.327) | 0.020 | ||
Other | 4.126 (0.429 to 39.682) | 0.22 | ||
Aetiology | ||||
HBV, HCV or other cirrhosis | 1 ref | |||
Alcohol | 1.354 (0.677 to 2.709) | 0.39 | ||
NASH | 1.195 (0.348 to 4.107) | 0.78 | ||
Other non-cirrohsis | 1.095 (0.251 to 4.776) | 0.90 | ||
Dyspnoea as presenting symptom | 4.087 (2.139 to 7.808) | <0.001 | 3.894 (2.018 to 7.514) | <0.0001 |
BMI≥30 vs BMI<30 | 0.860 (0.378 to 1.960) | 0.72 | ||
Diabetes mellitus (yes vs no) | 1.426 (0.748 to 2.717) | 0.28 | ||
Kidney function impairment with p-creatinine>2 mg/dL | 2.61 (1.142 to 5.972) | 0.023 | ||
Number of comorbidities | ||||
0 | 1 ref | |||
1 | 0.689 (0.298 to 1.595) | 0.38 | ||
2 | 0.831 (0.316 to 2.19) | 0.71 | ||
3+ | 2.071 (0.813 to 5.271) | 0.13 | ||
MELD class | ||||
MELD<15 | 1 ref | 1 ref | ||
MELD 15–19 | 5.267 (1.746 to 15.888) | 0.003 | 5.463 (1.808 to 16.5016) | 0.003 |
MELD≥20 | 6.055 (2.048 to 17.906) | 0.001 | 5.242 (1.768 to 15.545) | 0.003 |
BMI, Body Mass Index; HCC, hepatocellular carcinoma; LT, liver transplantation; MELD, Model for End-stage Liver Disease; ref, reference.