Summary of recent real-world studies of the performance of quantitative FIT in the prediction of colorectal cancer (CRC) in adults with clinical pointers to this diagnosis, showing data for FIT-negative cancers with IDA (reference 68 assessed all-cause anaemia rather than confirmed IDA)
| Reference | Number of subjects | Sensitivity of FIT for CRC | FIT-negative CRCs | ||
| Screened | CRC found | Total | No with IDA | ||
| Chapman et al64 | 795 | 40 | 87.5% | 5 | 5 |
| Mowat et al65 | 1447 | 95 | 87.4% | 12 | 7 |
| Nicholson et al66 | 9896 | 105 | 90.5% | 12 | 4 |
| D’Souza et al67 | 9822 | 329 | 90.9% | 30 | 4 |
| Lazlo et al68 | 3596 | 90 | 83.3% | 15 | 8 |
| Cunin et al69 | 1000 | 48 | 85.4% | 7 | 4 |
| Total | 26 556 | 707 | 81 | 32 | |
Data for an arbitrary detection threshold of 10 µg/g is shown for direct comparison.
FIT, faecal immunochemical testing; IDA, iron deficiency anaemia.