Variable | 32 weeks | 66 weeks | ||||||
CSAA | CDAA | CSAA | CDAA | |||||
WT | Ripk3−/− | WT | Ripk3−/− | WT | Ripk3−/− | WT | Ripk3−/− | |
Steatosis (0–3) | 0±0 | 1.7±0.§ | 3±0* | 3±0* | 1.3±0.7 | 3±0§ | 2.8±0.3§ | 3±0§ |
Inflammation (0–3) | 0±0 | 0.3±0.3 | 2±0* | 1±0.3§† | 0±0 | 0±0 | 2.3±0.5* | 0.8±0.3† |
Ballooning (0–2) | 0±0 | 0±0 | 1±0* | 1±0* | 0±0 | 0.3±0.3 | 1±0* | 1±0* |
NAS (0–8) | 0±0 | 2±0.6 | 6±0* | 5.3±0.3* | 1.3±0.7 | 3.3±0.3 | 6.5±0.4* | 4.7±0.3*† |
Fibrosis (0–4) | 0±0 | 0±0 | 1±0* | 1±0* | 0±0 | 0.3±0.3 | 2±0* | 1±0*† |
Values are mean±SEM of four individual mice.
§P<0.05 from CSAA diet WT mice at respective time-point.
*P<0.01 from CSAA diet WT mice at respective time-point.
†P<0.05 from CDAA diet WT mice at respective time-point.
CDAA, choline-deficient L-amino acid; CSAA, choline-sufficient L-amino acid; NAS, NAFLD activity score; WT, wild-type.