Clinical and neuropsychological data of the human replication cohort
| Total population (n=24) | Without obesity (n=12) | With obesity (n=12) | P value | |
| Age (years) | 53.5 (44.3–57.8) | 52 (39–58.3) | 53.5 (48.5–57.8) | 0.478 |
| Females n (%) | 15 (62.5) | 7 (58.3) | 8 (66.7) | 0.673 |
| Education (years) | 16 (15–17) | 17 (14–17) | 16 (15–17) | 1.9×10–5 |
| BMI (kg/m2) | 29.9 (23.2–45.1) | 23.2 (21.3–25.5) | 44.3 (38.6–47.7) | 3.2×10–5 |
| Waist (cm) | 96 (81–127) | 82 (72.8–87.8) | 127 (121–136) | 7.1×10–5 |
| Fat mass (%) | 37.4 (29.2–45.3) | 29.6 (21.3–34.9) | 45.2 (39.6–51.3) | 2.8×10–4 |
| SBP (mmHg) | 123.5 (115–136.8) | 116 (108–121.3) | 135.5 (124.5–148.3) | 0.001 |
| DBP (mmHg) | 69.5 (64.3–78.8) | 64.5 (59.5–69.5) | 78 (69.3–150.8) | 0.003 |
| HDL-C (mg/dL) | 56 (43–76) | 67 (58.3–77) | 44.5 (40–52.8) | 0.043 |
| Triglycerides (mg/dL) | 73 (48.8–117.5) | 57.5 (42.3–98.5) | 93 (68.5–150.8) | 0.069 |
| FPG (mg/dL) | 94.5 (84–103.8) | 92 (84–102) | 99 (85.3–103.8) | 0.418 |
| HbA1c (%) | 5.5 (5.3–5.8) | 5.5 (5.3–5.7) | 5.7 (5.3–6.3) | 0.147 |
| hsCRP (mg/dL) | 0.2 (0–0.5) | 0.1 (0–0.2) | 0.5 (0.2–0.8) | 0.009 |
| IGT (score) | 45 (42–49) | 44.5 (39–48.3) | 45.5 (43.3–49.8) | 0.271 |
| WCST (score) | 11 (11–12) | 11 (10.5–12.5) | 11 (11–12) | 0.918 |
Results are expressed as number and frequencies for categorical variables, mean and SD for normal distributed continuous variables and median and IQR for non-normal distributed continuous variables. To determine differences between study groups, we used χ2 for categorical variables, unpaired Student’s t-test in normal quantitative and Mann-Whitney U test for non-normal quantitative variables. P value determines differences between subjects with obesity (BMI ≥30 kg/m2) and without obesity (BMI 18.5–30 kg/m2).
BMI, body mass index; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C reactive protein; IGT, Iowa Gambling Test; SBP, systolic blood pressure; WCST, Wisconsin Card Sorting Test.