Clinical and neuropsychological data of the human discovery cohort
| Total population (n=114) | Without obesity (n=51) | With obesity (n=63) | P value | |
| Age (years) | 50.4 (41.8–58.6) | 53.9 (44.4–59.0) | 48.6 (40.7–57.5) | 0.096 |
| Females n (%) | 79 (69.3) | 34 (66.7) | 45 (71.4) | 0.584 |
| Education (years) | 12.5 (11–17) | 15 (12–17) | 12 (9–14) | 1.9×10–5 |
| BMI (kg/m2) | 34.6 (25.3–43.3) | 24.9 (2.6) | 43.1 (6.7) | 6.8×10–33 |
| Waist (cm) | 110 (92–126) | 89.8 (9.6) | 125.5 (14.0) | 5.8×10–29 |
| Fat mass (%) | 43.5 (33.8–50.2) | 32.4 (7.2) | 49.7 (5.5) | 2.7×10–24 |
| SBP (mmHg) | 132.8 (20.2) | 124.3 (15.8) | 139.5 (20.9) | 2.6×10–5 |
| DBP (mmHg) | 74.8 (11.6) | 71.2 (10.9) | 77.7 (11.4) | 0.003 |
| HDL-C (mg/dL) | 56 (45–68) | 66.0 (17.0) | 51.0 (12.9) | 4.1×10–7 |
| Triglycerides (mg/dL) | 90.5 (65.8–135.3) | 79 (58–96) | 124 (82–156) | 4.0×10–5 |
| FPG (mg/dL) | 96 (90–103) | 95 (89–101) | 97 (93–105) | 0.155 |
| HbA1c (%) | 5.5 (0.3) | 5.5 (5.3–5.6) | 5.6 (5.3–5.8) | 0.021 |
| hsCRP (mg/dL) | 1.8 (0.7–5.9) | 0.7 (0.4–1.3) | 4.9 (2.7–9.5) | 1.6×10–13 |
| SCWT (score) | 43.1 (10.1) | 45.9 (9.6) | 40.8 (10.0) | 0.006 |
Results are expressed as number and frequencies for categorical variables, mean and SD for normal distributed continuous variables and median and IQR for non-normal distributed continuous variables. To determine differences between study groups, we used χ2 for categorical variables, unpaired Student’s t-test in normal quantitative and Mann-Whitney U test for non-normal quantitative variables. P value determines differences between subjects with obesity (BMI ≥30 kg/m2) and without obesity (BMI 18.5–30 kg/m2).
BMI, body mass index; DBP, diastolic blood pressure; FPG, fasting plasma glucose; HbA1c, glycated haemoglobin; HDL-C, high-density lipoprotein cholesterol; hsCRP, high-sensitivity C reactive protein; SBP, systolic blood pressure; SCWT, Stroop Color and Word Test.