Table 3

Quantification of HBV DNA integrations involving intron/exon human regions by droplet digital PCR

Patient no.Human genomic regions*HBV regionsNumber of HBV integrations/1000 hepatocytes†
39 ELAC2 intron-10 HBx 8
40 IFITM1 intron-1 HBx 4
IFITM1 intron-1 Core 5
44 NUP85 intron-3 Pol 3
62 ANKRD52 intron-7 Pol 158
ANKRD52 intron-7 HBx 157
75 AGBL5 intron-12 HBx/Core 7
83 NR3C1 exon-5 HBx 4
84 CYP2U1 intron-4 HBx 0.5
  • *The human genomic regions involved in HBV integrations were retrieved by ANNOVAR software.

  • †HBV integrations were quantified by digital droplet PCR assays.

  • HBx, hepatitis B X protein.