Change of eight domains of quality of life after G-POEM measured with SF-36 questionnaire
| Pre G-POEM (n=80/80, 100%) | 1 month (n=72/80, 90%) | 3 months (n=64/80, 80%) | 6 months (n=61/80, 76%) | 12 months (n=72/80, 90%) | Difference between baseline and 12 months | Change over the course of the study | Change between baseline and 12 months | |
| Median (25th–75th percentiles) | Median (25th–75th percentiles) | Median (25th–75th percentiles) | Median (25th–75th percentiles) | Median (25th–75th percentiles) | Mean (95% CI) | P value* | P value† | |
| Physical functioning | 70 (35–91.25) | 77.5 (50–98.75) | 82.5 (45–95) | 85 (60–97.5) | 87.5 (56.25–100) | −14.8 (−21.6 to −8) | 0.071 | <0.001 |
| Role limitation due to physical health | 0 (0–75) | 25 (0–100) | 50 (0–100) | 50 (0–100) | 62.5 (0–100) | −14.5 (−25.3 to −3.7) | 0.085 | 0.008 |
| Role limitation due to emotional problems | 66.7 (0–100) | 100 (0–100) | 100 (33.3–100) | 100 (33.3–100) | 100 (33.3–100) | −14.2 (−26.7 to −1.6) | <0.001 | 0.034 |
| Vitality | 40 (20–55) | 50 (30–65) | 55 (27.5–70) | 50 (30–70) | 50 (30–75) | −14 (−20.3 to −7.7) | 0.002 | <0.001 |
| Mental health | 64 (52–80) | 68 (57–83) | 68 (56–83) | 72 (60–80) | 72 (56–88) | −6.3 (−11.7 to −0.9) | 0.004 | 0.038 |
| Social functioning | 50 (25–62.5) | 56.25 (50–87.5) | 62.5 (38.125–87.5) | 75 (50–87.5) | 75 (37.5–100) | −18.6 (−25.4 to −11.9) | <0.001 | <0.001 |
| Bodily pain | 45 (22.5–67.5) | 57.5 (32.5–80) | 57.5 (33.125–85.625) | 57.5 (43.125–87.5) | 68.75 (45–90) | −19.8 (−27.2 to −12.3) | 0.216 | <0.001 |
| General health | 37.5 (25–55) | 45 (30–61.25) | 45 (30–65) | 45 (27.5–65) | 40 (25–65) | −5.3 (−10.4 to −0.3) | 0.004 | 0.021 |
Bold indicates a statistically significant difference with a p-value less than 0.05.
*P values were determined from tests for trend using repeated-measures analysis whether the domains of quality of life improve over time (Friedman’s test).
†P values were determined by comparing 12 months and baseline values (Wilcoxon signed ranks test).
G-POEM, gastric per-oral endoscopic myotomy; SF-36, 36-Item Short Form.