Pooled-analysis of AID-1 (n=685) and AID-2 (n=660) data: results from a two-level logistic regression model with adenoma detection as the outcome and patient’s characteristics (ie, age, gender, colonoscopy indication) and endoscopist’s experience as the regression
| Adenoma detection rate | Advanced neoplasia detection rate | ||||
| Variables | Comparison | RR | 95% CI | RR | 95% CI |
| Study arm | Control group | 1 | – | 1 | – |
| CADe | 1.29 | 1.16 to 1.42 | 1.13 | 0.84 to 1.50 | |
| Age (years) | As continuous variable, mean centering | 1.03 | 1.02 to 1.04 | 1.04 | 1.02 to 1.05 |
| Gender | Female | 1 | 1 | ||
| Male | 1.34 | 1.20 to 1.48 | 1.32 | 0.98 to 1.75 | |
| Colonoscopy indication | FIT+ | 1 | – | 1 | – |
| Surveillance | 1.01 | 0.85 to 1.17 | 0.38 | 0.24 to 0.59 | |
| Screening | 0.76 | 0.60 to 0.93 | 0.43 | 0.26 to 0.67 | |
| Diagnostic | 0.77 | 0.62 to 0.94 | 0.34 | 0.21 to 0.56 | |
| Experience | Experienced | 1 | 1 | ||
| Non-experienced | 1.02 | 0.89 to 1.16 | 1.37 | 0.97 to 1.91 | |
| Random part | Estimate | 95% CI | Estimate | 95% CI | |
| Between colonoscopist standard deviation (null model) | 0.20 | 0.03 to 0.41 | 0.15 | 0.19 to 0.70 | |
| Intraclass correlation coefficient | 0.01 | 0.05 | 0.05 | ||
CADe, computer-aided detection; FIT, faecal immunochemical test; RR, relative risk.