Table 3

Multivariate model for progression to advanced neoplasia (AN) within the discovery set

Risk factor in final modelHR
(95% CI)
P value
Visible index LGD size 10 mm or more2.7 (1.2 to 5.9)0.01400
Index LGD not endoscopically resected or incomplete resection3.4 (1.6 to 7.4)0.00190
Multifocal LGD at time of index LGD diagnosis2.9 (1.3 to 6.2)0.00749
Moderate or severe active histological inflammation in any colonic segment at time of or within previous 5 years of index LGD diagnosis3.1 (1.5 to 6.7)0.00305
  • Risk factors for LGD progression to high-grade dysplasia or colorectal cancer (multivariate Cox regression analysis). n=246 total patients included with complete data available, 29 progressed to AN. Score (log rank) overall p=9e-10 for model.

  • LGD, low-grade dysplasia.