Patient and baseline characteristics from the intention-to-treat analysis
| Variable | Level | Total (n=55) | Placebo (n=28) | Famotidine (n=27) | P value* |
| Patients’ characteristics | |||||
| Age (year) | 35.0±20.0 | 31.5±13.0 | 35.0±18.0 | 0.162 | |
| Gender | Female | 35 (63.6%) | 18 (64.3%) | 17 (63.0%) | 0.919 |
| Male | 20 (36.4%) | 10 (35.7%) | 10 (37.0%) | ||
| Race | American Indian or Alaskan Native | 1 (1.8%) | 0 (0.0%) | 1 (3.7%) | 0.862 |
| Black or African American | 18 (32.7%) | 10 (35.7%) | 8 (29.6%) | ||
| More than one race | 12 (21.8%) | 7 (25.0%) | 5 (18.5%) | ||
| Unknown/not reported | 2 (3.6%) | 1 (3.6%) | 1 (3.7%) | ||
| White | 22 (40.0%) | 10 (35.7%) | 12 (44.4%) | ||
| Ethnicity | Hispanic or Latino | 14 (25.5%) | 5 (17.9%) | 9 (33.3%) | 0.386 |
| Not Hispanic or Latino | 22 (40.0%) | 13 (46.4%) | 9 (33.3%) | ||
| Unknown/not reported | 19 (34.5%) | 10 (35.7%) | 9 (33.3%) | ||
| COVID-19 symptom score at baseline† | |||||
| Total symptom score | 18.0±11.0 | 18.0±13.0 | 18.0±10.0 | 0.985 | |
| History of present illness | |||||
| Symptomatic days prior to randomisation | 4.0±3.0 | 4.0±2.0 | 4.0±3.0 | 0.363 | |
| Vital signs at baseline‡ | |||||
| BMI (kg/m2) | 27.33±7.78 | 25.43±8.28 | 28.93±6.69 | 0.149 | |
| Temperature (°F) | 98.30±0.80 | 98.30±0.80 | 98.50±0.77 | 0.253 | |
| Heart rate (bpm) | 88.0±19.0 | 87.0±23.0 | 89.0±16.5 | 0.385 | |
| SpO2 (%) | 99.0±2.0 | 99.0±3.0 | 99.0±1.5 | 0.992 | |
| FEV1/FVC | 0.88±0.23 | 0.88±0.19 | 0.88±0.25 | 0.614 | |
For the continuous variable, median±IQR was reported.
*For categorical variables, p values were based on χ2 test with exact p value from Monte Carlo simulation; for the continuous variable, the p value was based on Wilcoxon rank sum test.
†Reason of missing data: IRB013 in placebo group, IRB041 and IRB052 in famotidine group withdrew early without baseline symptom scores.
‡Reason of missing data: IRB013 in placebo group, IRB041, IRB044, IRB052 in famotidine group withdrew early/were lost to follow-up without baseline vitals completed.
BMI, body mass index.