PPI-dependent heartburn | Healthy controls | P | |
Male gender (n) (%) | 232 (48%) | 45 (64%) | 0.013 |
Age (years) (mean) (SD) | 50 (14) | 40 (14) | <0.0001 |
AET (%) (mean) (SD) | 6.7 (5.9) | 0.9 (0.9) | <0.0001 |
TRs (n) (mean) (SD) | 58 (38) | 21 (14) | <0.0001 |
PSPW index (%) (mean) (SD) | 31 (18) | 72 (17) | <0.0001 |
MNBI (Ω) (mean) (SD) | 1565 (837) | 2990 (835) | <0.0001 |
Concordant SAP/SI positivity (n) (%) | 213 (44%) | / | / |
AET, acid exposure time; MNBI, mean nocturnal baseline impedance; PPI, proton pump inhibitor; PSPW, post-reflux swallow-induced peristaltic wave; SAP, symptom association probability; SI, symptom index; ; TRs, total refluxes.