Table 1

Baseline characteristics of 488 patients with PPI-dependent heartburn and of 70 healthy controls

PPI-dependent heartburnHealthy controlsP
Male gender (n) (%)232 (48%)45 (64%)0.013
Age (years) (mean) (SD)50 (14)40 (14)<0.0001
AET (%) (mean) (SD)6.7 (5.9)0.9 (0.9)<0.0001
TRs (n) (mean) (SD)58 (38)21 (14)<0.0001
PSPW index (%) (mean) (SD)31 (18)72 (17)<0.0001
MNBI (Ω) (mean) (SD)1565 (837)2990 (835)<0.0001
Concordant SAP/SI positivity (n) (%)213 (44%)//
  • AET, acid exposure time; MNBI, mean nocturnal baseline impedance; PPI, proton pump inhibitor; PSPW, post-reflux swallow-induced peristaltic wave; SAP, symptom association probability; SI, symptom index; ; TRs, total refluxes.