Baseline characteristics, stratified by genetic risk category
|
| Mutation carriers (n=165) | FPC kindreds (n=201) | P value |
| Age, mean (SD), years | 52 (9.6) | 56 (9.8) | <0.001 |
| Male sex, n (%) | 73 (44) | 84 (42) | 0.64 |
| BMI, median (IQR) | 25 (4.5) | 25 (5) | 0.46 |
| Gene mutation, n (%) | – | ||
| CDKN2A p16 | 96 (58) | – | – |
| BRCA2 + ≥2 blood relatives with PDAC | 45 (27) | – | – |
| BRCA2 + ≥1 FDR with PDAC | 25 | – | – |
| BRCA2 + ≥1 SDR with PDAC but no FDR with PDAC | 9 | – | – |
| BRCA2 without FDR or SDR with PDAC | 11 | – | – |
| BRCA1 + ≥2 blood relatives with PDAC | 7 (4) | – | – |
| BRCA1 + ≥1 FDR with PDAC | 6 | – | – |
| BRCA1 + ≥1 SDR with PDAC but no FDR with PDAC | 1 | – | – |
| PALB2 + 3 blood relatives with PDAC | 2 (1) | – | – |
| STK11/LKB1 | 9 (6) | – | – |
| TP53 + 2 blood relatives with PDAC | 5 (3) | – | – |
| TP53 + ≥1 FDR with PDAC | 2 | – | – |
| TP53 + ≥1 SDR with PDAC but no FDR with PDAC | 3 | – | – |
| ATM + 3 FDR with PDAC | 1 (1) | – | – |
| Total number of any degree blood relatives with PDAC, n (%) | <0.001 | ||
| 0 | 32 (19) | – | – |
| 1 | 24 (15) | – | – |
| 2 | 49 (30) | 104 (52) | – |
| 3 or more | 56 (34) | 96 (48) | – |
| Age youngest blood relative with PDAC, median (IQR), years | 49 (16) | 56 (15) | <0.001 |
| Blood relative with PDAC <50 years of age, n (%) | 65 (39) | 58 (29) | <0.001 |
| Personal history of non-pancreatic malignancy, n (%) | 81 (49) | 24 (12) | <0.001 |
| Personal history of diabetes mellitus, n (%) | 3 (2) | 13 (7) | 0.03 |
| Personal history of acute pancreatitis, n (%) | 0 (0) | 7 (4) | 0.02 |
| Smoking, n (%) | 0.32 | ||
| Never | 78 (47) | 101 (50) | – |
| Former | 68 (41) | 67 (33) | – |
| Current | 17 (10) | 31 (15) | – |
| Alcohol use, n (%) | 0.88 | ||
| Never | 39 (24) | 42 (21) | – |
| Former | 7 (4) | 11 (6) | – |
| Current | 116 (70) | 145 (72) | – |
By definition, FPC kindreds do not carry any of the known PDAC susceptibility gene mutations and have two or more blood relatives affected with PDAC. For the total number of blood relatives with PDAC, smoking and alcohol use, percentages may not add up to 100% because of missing data in up to 2% of participants.
FDR, first-degree blood relative; FPC, familial pancreatic cancer; PDAC, pancreatic ductal adenocarcinoma; SDR, second-degree blood relative.