Type-A DNA methylation at gene promoters targets specific signalling pathways
| Pathway name | Fold enrichment | False discovery rate-corrected p value |
| Axon guidance mediated by Slit/Robo | 6.42 | 5.37×10–4 |
| Ionotropic glutamate receptor pathway | 3.87 | 4.18×10–3 |
| Cadherin signalling pathway | 2.94 | 6.71×10–5 |
| Metabotropic glutamate receptor group III pathway | 2.87 | 0.0345 |
| Heterotrimeric G-protein signalling pathway-Gi alpha and Gs alpha mediated | 2.37 | 5.67×10–3 |
| Alzheimer disease-presenilin pathway | 2.3 | 0.0368 |
| Heterotrimeric G-protein signalling pathway-Gq alpha and Go alpha mediated | 2.27 | 0.0476 |
| Wnt signalling pathway | 2.09 | 9.11×10–4 |
Type-A CpGs were identified as those significantly associated with age in the intestine of wild-type animals from weaning. CpGs were assessed by regression analyses and pathway enrichment determined using the PANTHER enrichment tool.