Table 5

PANTHER pathway enrichment for differentially methylated genes in BrafW-5 vs Braf 9–14 animals

Pathway nameFold enrichmentP valueFDR-corrected p value
Type-A
No significant pathway enrichment
Type-AB
Ionotropic glutamate receptor pathway5.91.34×10–4 5.56×10–3
Cadherin signalling pathway4.882.81×10–8 4.66×10–6
Wnt signalling pathway2.782.30×10–5 1.27×10–3
Type-B
Ionotropic glutamate receptor pathway6.695.71×10–5 3.16×10–3
Metabotropic glutamate receptor group III pathway5.656.56×10–5 2.72×10–3
Heterotrimeric G-protein signalling pathway-Gi alpha and Gs4.292.94×10–6 4.87×10–4
Heterotrimeric G-protein signalling pathway-Gq alpha and Go3.882.35×10–4 7.79×10–3
Cadherin signalling pathway3.324.62×10–4 0.0128
  • Enrichment analysis was performed on genes with at least one differentially methylated CpG site mapping to the promoter region of the gene and is stratified for methylation type.