Table 2

Change in duodenal polyp burden from baseline

Change (month 6–baseline), mean (SD)
No. of participantsBaseline, mean (SD)Month 6, mean (SD)Absolute
change mean (SD)
% change, mean (SD)% change
(95% CI)
P value
Duodenal polyp burden, mm
All evaluable participants42137.2 (112.42)97.2 (81.52)−40.0 (64.42)−29.6 (31.94)−39.6 to −19.7<0.0001*
Severity of duodenal polyposis
 Spigelman 332159.6 (119.18)114.1 (85.06)−45.4 (71.79)−27.0 (32.65)−38.7 to −15.2<0.0001*
 Spigelman 21065.6 (34.34)42.9 (32.61)−22.7 (26.80)−38.1 (29.55)−59.2 to −16.90.0028*
APC genetic mutation
 Yes36143.8 (117.41)101.4 (84.48)−42.3 (69.11)−29.1 (33.61)−40.5 to −17.8<0.0001*
 No697.7 (70.39)71.5 (60.16)−26.2 (18.05)−32.4 (21.14)−54.6 to −10.20.0133*
Rash acneiform/maculopapular
 Yes23145.6 (138.29)99.7 (95.13)−45.9 (82.69)−31.4 (37.00)−47.4 to −15.40.0005*
 No19127.0 (72.21)94.1 (63.71)−32.9 (31.62)−27.5 (25.33)−39.7 to −15.20.0002*
Sex
 Female19136.5 (87.05)103.2 (66.97)−33.3 (33.68)−26.0 (22.76)−37.0 to −15.0<0.0001*
 Male23137.7 (131.73)92.2 (93.05)−45.6 (82.07)−32.6 (38.18)−49.1 to −16.00.0005*
Median age
 ≤4221128.8 (98.67)85.7 (81.85)−43.1 (40.20)−39.1 (23.44)−49.8 to −28.5<0.0001*
 >4221145.6 (126.59)108.6 (81.55)−37.0 (82.90)−20.1 (36.76)−36.8 to −3.30.0211*
  • *Paired t-test of observed mean change, %, against 0%.

  • †Paired signed-rank test of observed median change, %, against 0%.

  • APC, aerobic plate count; FAP, familial adenomatous polyposis.