Systematic reviews of FIT diagnostic accuracy for CRC at a cut-off of 10 µg/g in symptomatic patients
| Design | n | Analyser | Reference standard | CRC sensitivity @ 10 µg/g | CRC specificity @ 10 µg/g | |
| Westwood et al 63 | SR | 4091 | OC-Sensor | Various | 92.1% (86.9% to 95.3%) | 85.8% (78.3% to 91.0%) |
| Pin Vieito et al 65 | SR | 4035 | OC-Sensor | Various | 94.1% (90.0% to 96.6%) | 66.0% (47.1% to 80.9% |
| Stonestreet et al 66 | SR | 4096 | OC-Sensor | Various | 93%* (88% to 0.96%) | 87%* (83% to 90%) |
| Pin Vieito et al 65 | SR | 48 872 | OC-Sensor/ HM-JACKarc | Various | 87.2% (81.0% to 91.6%) | 84.4% (79.4% to 88.3%) |
| Saw et al 71 | SR | 25 500 | OC-Sensor/ HM-JACKarc/ FOB Gold/ QuikRead Go | Various | 88.7% (85.2% to 91.4%) | 80.5% (75.3% to 84.8%) |
| Booth et al 61 | SR | 35 945 | OC-Sensor/ HM-JACKarc/ FOB Gold/ QuikRead Go | Colonoscopy and CT | 91.0% (88.9% to 92.7%) | 75.2% (69.6% to 80.1%) |
95% CIs given in brackets when reported.
*10–15 µg/g.
CRC, colorectal cancer; CTC, CT colonography; FIT, faecal immunochemical testing; SR, systematic review and meta-analysis.