Clinical predictors of induction remission to faecal microbiota transplantation and anti-inflammatory diet at 8 weeks
| No remission (n=14) | Remission (n=21) | P value | OR with 95% CI | |
| Age (years), median (IQR) | 33.5 (25–50) | 30 (24.5–39) | 0.38 | 0.97 (0.9 to 1.04) |
| Gender (male), n (%) | 8 (57.1) | 12 (57.1) | 1 | 1 (0.26 to 3.9) |
| Disease duration (months), median (IQR) | 48 (36–99) | 36 (17–90) | 0.34 | 0.99 (0.99 to 1.0) |
| Extent (left-sided colitis), n (%) | 7 (50) | 15 (71.4) | 0.19 | 2.5 (0.6 to 10.3) |
| Disease severity, n (%) | ||||
| Mild Moderate | 5 (35.7) 9 (64.3) | 16 (76.2) 5 (23.8) | 0.02 | 5.7 (1.3 to 25.4) |
| Past immunomodulator, n (%) | 11 (78.6) | 10 (47.6) | 0.07 | 0.25 (0.05 to 1.2) |
| Past steroid use, n (%) | ||||
| Never First year Steroid dependent ASUC | 0 10 (71.4) 5 (35.7) 2 (14.3) | 5 (23.8) 10 (47.6) 8 (38.1) 3 (14.3) | 0.05 0.16 0.89 1 | 0.36 (0.09 to 1.6) 1.11 (0.3 to 4.5) 1 (0.1 to 6.9) |
| Median (IQR) SCCAI | 7 (6–7) | 6 (4–6.5) | 0.02 | 1.8 (1.04 to 3.2) |
| Median (IQR) UCEIS | 4 (3–5) | 4 (3–4) | 0.63 | 0.96 (0.5 to 1.7) |
| Haemoglobin (gm/dL), median (IQR) | 11.6 (9.8–12.7) | 11.8 (10.3–13.1) | 0.86 | 0.97 (0.7 to 1.3) |
| Platelet count (109/L), median (IQR) | 296 (219–337) | 280 (200–370) | 0.93 | 1.0 (0.99 to 1.0) |
| Albumin (gm/dL), median (IQR) | 4.4 (4–4.6) | 4.4 (4–4.6) | 0.73 | 0.98 (0.2 to 5.5) |
| C-reactive protein (mg/L), median (IQR) | 3.7 (1.4–5.2) | 3.04 (0.5–12.7) | 0.88 | 1.01 (0.9 to 1.1) |
| Faecal calprotectin, µg/g, median (IQR) | n=13, 479.6 (336.9–538.7) | n=19, 309 (281– 476) | 0.15 | 0.99 (0.99 to 1.0) |
Mild disease: SCCAI 3–6, moderate: SCCAI 7–9.
5-ASA, 5-aminosalicylic acid; ASUC, acute severe ulcerative colitis; FMT-AID, faecal microbiota transplantation and anti-inflammatory diet; SCCAI, Simple Clinical Colitis Activity Index; SMT, standard medical therapy; UCEIS, Ulcerative Colitis Endoscopic Index of Severity.