Table 1

Study population characteristics and outcomes

	Participants	Advanced neoplasia				Colorectal cancer
	n (%)	n	OR	95% CI	P value	n	OR	95% CI	P value
All	265 881 (100)	3254	–			557	–
Sex
Female	138 860 (52.2)	1325	Ref		<0.001	248	Ref		<0.001
Male	127 021 (47.8)	1929	1.6	1.5 to 1.7		309	1.4	1.2 to 1.6
Age, years (mean 69.0±1.9)
64	10 778 (4.1)	138	Ref		0.01	17	Ref		0.11
65	1118 (0.4)	13	0.9	0.5 to 1.6		2	1.1	0.3 to 4.9
66	6378 (2.4)	70	0.9	0.6 to 1.1		11	1.1	0.5 to 2.3
67	54 701 (20.6)	656	0.9	0.8 to 1.1		107	1.2	0.7 to 2.1
68	12 793 (4.8)	156	1.0	0.8 to 1.2		18	0.9	0.5 to 1.7
69	74 344 (28)	824	0.9	0.7 to 1.0		148	1.3	0.8 to 2.1
70	20 189 (7.6)	248	1.0	0.8 to 1.2		39	1.2	0.7 to 2.2
71	85 298 (32.1)	1145	1.0	0.9 to 1.3		214	1.6	1.0 to 2.6
72	282 (0.1)	4	1.1	0.4 to 3.0		1	2.3	0.3 to 17
First F-Hb concentration, µg Hb/g faeces
0	206 983 (77.8)	1356	Ref		<0.001	273	Ref		<0.001
0.1–2.5	27 861 (10.5)	444	2.5	2.2 to 2.7		71	1.9	1.5 to 2.5
2.6–9.9	19 661 (7.4)	643	5.1	4.7 to 5.6		97	3.8	3.0 to 4.7
10–19.9	6930 (2.6)	395	9.2	8.2 to 10.3		58	6.4	4.8 to 8.5
20–29.9	2258 (0.8)	183	13.4	11.4 to 15.7		32	10.9	7.5 to 15.7
30–39.9	1361 (0.5)	129	15.9	13.1 to 19.2		13	7.3	4.2 to 12.8
40–46.9	827 (0.3)	104	21.8	17.6 to 27.0		13	12.1	6.9 to 21.2
Second F-Hb concentration, µg Hb/g faeces
0	242 220 (91.1)	1745	Ref		<0.001	346	Ref		<0.001
0.1–2.5	5322 (2.0)	174	4.7	4.0 to 5.5		38	5.0	3.6 to 7.0
2.6–9.9	8253 (3.1)	455	8.0	7.2 to 8.9		57	4.9	3.7 to 6.4
10–19.9	4887 (1.8)	362	11.0	9.8 to 12.4		55	8.0	6.0 to 10.6
20–29.9	2362 (0.9)	230	14.9	12.9 to 17.2		25	7.5	5.0 to 11.2
30–39.9	1742 (0.7)	173	15.2	12.9 to 17.9		22	8.9	5.8 to 13.8
40–46.9	1095 (0.4)	115	16.2	13.3 to 19.7		14	9.1	5.3 to 15.5

ORs were based on raw numbers. Adjusted ORs are presented in table 2. Associations were examined using Pearson’s χ² test.
F-Hb, faecal haemoglobin.