Literature search process
| Searches (inception to 1 February 2023) | Results | |
| 1 | Colorectal neoplasms/or colonic neoplasms/or rectal neoplasms/ | 216 237 |
| 2 | (colorectal cancer or colorectal adenoma) title, abstract | 104 818 |
| 3 | Biomarkers, tumour/or DNA methylation/or carcinoembryonic antigen/or neoplasm proteins/or epigenomics/ | 312 575 |
| 4 | (biomarker* or molecular marker* or cancer maker* or haemoglobin or carcinoembryonic antigen or stool or faecal or faeces or urine or methylation or hypomethylat* or hypermethylat* or epigenetic) title, abstract | 826 506 |
| 5 | “Systematic review”/or meta-analysis/or (systematic review or meta-analysis) pt or (systematic review or meta-analysis) title, abstract | 336 895 |
| 6 | Early detection of cancer/or predictive value of tests/or prognosis/or risk factors/ | 1 635 367 |
| 7 | (screening or predictive or prediction or predicting or diagnos* or prognostic or prognosis) title, abstract | 3 809 084 |
| 8 | 1 or 2 | 232 868 |
| 9 | 3 or 4 | 1 017 702 |
| 10 | 6 or 7 | 4 699 370 |
| 11 | 5 and 8 and 9 and 10 | 770 |
| 12 | Animals/not humans/ | 5 053 862 |
| 13 | 11 not 12 | 769 |
pt, publication type.