Table 2

Multivariable logistic regression analyses for impact of (A) the invitation time period or (B) invitation interval on the detection of AN and interval CRC in the subsequent invitation round

	PPV for CRC				PPV for AN†				Detection rate for CRC				Detection rate for AN†
	%	OR	95% CI		%	OR	95% CI		%	OR	95% CI		%	OR	95% CI
A. Invitation period
Before	5.3	Ref			34.7	Ref*			0.19	Ref			1.25	Ref
During	4.6	0.91	0.81	1.1.03	31.8	0.91	0.86	0.96	0.16	0.90	0.80	1.01	1.09	0.92	0.88	0.96
After	4.2	0.91	0.84	0.99	32.0	0.95	0.92	0.98	0.14	0.92	0.85	0.99	1.07	0.97	0.94	1.00
B. Invitation interval (months)
≤24–25	5.1	Ref			33.9	Ref			0.18	Ref			1.20	Ref
25–26	4.7	1.02	0.89	1.17	32.9	1.02	0.96	1.09	0.16	1.04	0.92	1.19	1.11	0.78	0.75	1.09
26–27	4.6	1.01	0.89	1.14	31.9	1.01	0.96	1.07	0.15	1.02	0.91	1.15	1.07	1.04	0.99	1.07
27–28	3.9	0.89	0.77	1.02	31.3	0.98	0.92	1.04	0.13	0.93	0.81	1.07	1.06	1.02	0.98	1.08
28–29	4.1	0.89	0.74	1.08	33.4	1.05	0.97	1.14	0.14	0.94	0.78	1.13	1.15	1.02	0.97	1.16
>29	4.3	0.92	0.72	1.17	32.8	1.04	0.94	1.15	0.28	0.94	0.74	1.19	2.16	1.09	1.02	1.13

All ORs are adjusted for confounding variables age, sex and invitation round.
*Ref indicates that the alternative model (including the time period) better fitted the data. All ORs are presented for the alternative model including time period, regardless if it improved the model.
†AN is the combination of colorectal cancer and advanced neoplasia.
AN, advanced neoplasia; CRC, colorectal cancer; PPV, positive predictive value.