Table 2

Results of multivariate Cox regression analysis investigating role of persistent VA in the development of complications and mortality

HR (95% CI)P value*
Development of complications
 Persistent VA at follow-up duodenal biopsy9.53 (4.77 to 19.04)<0.001
 Age at diagnosis ≥45 years2.17 (1.10 to 4.29)0.03
 Classical pattern of CD3.03 (1.52 to 6.02)<0.01
 Male sex1.21 (0.65 to 2.23)0.55
Mortality
 Persistent VA at follow-up duodenal biopsy2.93 (1.43 to 6.02)<0.01
 Age at diagnosis ≥45 years9.45 (2.81 to 31.80)<0.001
 Classical pattern of CD1.16 (0.57 to 2.36)0.68
 Male sex1.24 (0.59 to 2.62)0.57
  • *P<0.05 for statistical significance.

  • CD, coeliac disease; VA, villous atrophy.