Table 1

Demographics and clinical characteristics of the patients included in this study

Characteristics*SwedenSpainTotal†
IBS-D patients203050
Females (%)12 (60.0)19 (63.3)31 (62.0)
Age, mean±SD48.9±13.442.8±13.945.2±13.9
IBS-SSS (mean±SD) at baseline282.4±69.3293.8±71.1289.2±69.9
IBS-SSS (mean±SD) at 2 weeks194.1±100.3183.8±89.7187.9±93.2
IBS-SSS (mean±SD) at 4 weeks157.3±93.2142.5±99.0148.4±94.1
Responders at 2 weeks (%)‡15 (75.0)20 (66.7)35 (70.0)
Responders at 4 weeks (%)‡17 (85.0)25 (83.3)42 (84.0)
SI hypomorphic genotype (0/1/2)§12/4/415/11/427/15/8
  • *Demographic, IBS symptom severity scores (IBS-SSS) and SSRD response during the observation period, at 2 and 4 weeks (standard deviation (SD)).

  • †Swedish and Spanish patients did not significantly differ for age, sex, IBS-SSS scores or SSRD response rates.

  • ‡A positive SSRD response was defined as a drop of 50 IBS-SSS points, compared with baseline.

  • §SI hypomorphic genotype (non-carriers/single-carriers/double-carriers).

  • IBS, irritable bowel syndrome; SI, sucrase-isomaltase; SSRD, sucrose and starch-restricted diet.