Table 1

Significant associations between hCAZymes genes and risk of IBS

IBS definitionOR (95% CI)P valuePFDR
Single-gene analyses*
SISelf-IBS1.1 (1.0 to 1.3)0.01010.0296
SIHA-IBS1.1 (1.0 to 1.3)0.02030.0296
SIRome-IBS1.1 (1.0 to 1.2)0.02220.0296
AMY1BHA-IBS1.7 (1.1 to 2.7)0.00780.0311
AMY2AHA-IBS1.5 (1.1 to 2.2)0.00790.0317
Multiple gene analyses
 Any geneHA-IBS1.2 (1.1 to 1.3)0.00150.0059
 Any geneSelf-IBS1.2 (1.0 to 1.3)0.00300.0061
 Any geneRome-IBS1.1 (1.0 to 1.2)0.01430.0190
 Number of genes affectedHA-IBS1.2 (1.1 to 1.3)0.00110.0045
Number of genes affectedSelf-IBS1.2 (1.1 to 1.3)0.00400.0079
Number of genes affectedRome-IBS1.1 (1.0 to 1.2)0.01510.0201
  • *Studying carriers of hCAZyme hypomorphic variants in individual genes.

  • †Studying carriers of hCAZyme hypomorphic variants in any gene (AMY1B, AMY2A or SI) and as a function of the number of genes affected.

  • AMY, amylase genes; HA-IBS, Hospital inpatient Admissions IBS; hCAZymes, human Carbohydrate-Active enZymes; IBS, irritable bowel syndrome; Rome-IBS, Rome III Criteria from the Digestive Health Questionnaire IBS ; Self-IBS, Self-reported IBS; SI, sucrase-isomaltase gene.