antibody targeted therapy

Vedolizumab affects antibody responses to immunisation selectively in the gastrointestinal tract: randomised controlled trial results
Tim Wyant, Tim Leach, Serap Sankoh, Yuemei Wang, Jonathan Paolino, Marcela F Pasetti, Brian G Feagan, Asit Parikh

Gut Jan 2015, 64 (1) 77-83; DOI: 10.1136/gutjnl-2014-307127
Anti-IP-10 antibody (BMS-936557) for ulcerative colitis: a phase II randomised study
Lloyd Mayer, William J Sandborn, Yuriy Stepanov, Karel Geboes, Robert Hardi, Michael Yellin, Xiaolu Tao, Li An Xu, Luisa Salter-Cid, Sheila Gujrathi, Richard Aranda, Allison Y Luo

Gut Mar 2014, 63 (3) 442-450; DOI: 10.1136/gutjnl-2012-303424
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice
Mamdouh A K Sedhom, Mélanie Pichery, Jenna R Murdoch, Benoit Foligné, Nathalie Ortega, Sylvain Normand, Kirsten Mertz, Devika Sanmugalingam, Lea Brault, Teddy Grandjean, Emma Lefrancais, Padraic G Fallon, Valérie Quesniaux, Laurent Peyrin-Biroulet, Gieri Cathomas, Tobias Junt, Mathias Chamaillard, Jean-Philippe Girard, Bernhard Ryffel

Gut Dec 2013, 62 (12) 1714-1723; DOI: 10.1136/gutjnl-2011-301785
A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis
Paul J Rutgeerts, Richard N Fedorak, Daan W Hommes, Andreas Sturm, Daniel C Baumgart, Brian Bressler, Stefan Schreiber, John C Mansfield, Marna Williams, Meina Tang, Jennifer Visich, Xiaohui Wei, Mary Keir, Diana Luca, Dimitri Danilenko, Jackson Egen, Sharon O'Byrne

Gut Aug 2013, 62 (8) 1122-1130; DOI: 10.1136/gutjnl-2011-301769
Secukinumab failure in Crohn's disease: the yeast connection?
Jean Frédéric Colombel, Boualem Sendid, Thierry Jouault, Daniel Poulain

Gut May 2013, 62 (5) 800-801; DOI: 10.1136/gutjnl-2012-304154
Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
Wolfgang Hueber, Bruce E Sands, Steve Lewitzky, Marc Vandemeulebroecke, Walter Reinisch, Peter D R Higgins, Jan Wehkamp, Brian G Feagan, Michael D Yao, Marek Karczewski, Jacek Karczewski, Nicole Pezous, Stephan Bek, Gerard Bruin, Bjoern Mellgard, Claudia Berger, Marco Londei, Arthur P Bertolino, Gervais Tougas, Simon P L Travis, for the Secukinumab in Crohn's Disease Study Group

Gut Dec 2012, 61 (12) 1693-1700; DOI: 10.1136/gutjnl-2011-301668
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer
Carlo Schneider, Andreas Teufel, Tetyana Yevsa, Frank Staib, Anja Hohmeyer, Gudrun Walenda, Henning W Zimmermann, Mihael Vucur, Sebastian Huss, Nikolaus Gassler, Hermann E Wasmuth, Sergio A Lira, Lars Zender, Tom Luedde, Christian Trautwein, Frank Tacke

Gut Dec 2012, 61 (12) 1733-1743; DOI: 10.1136/gutjnl-2011-301116

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