cancer immunobiology

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
Zhewen Xiong, Stephen Lam Chan, Jingying Zhou, Joaquim S.L. Vong, Tsz Tung Kwong, Xuezhen Zeng, Haoran Wu, Jianquan Cao, Yalin Tu, Yu Feng, Weiqin Yang, Patrick Pak-Chun Wong, Willis Wai-Yiu Si-Tou, Xiaoyu Liu, Jing Wang, Wenshu Tang, Zhixian Liang, Jiahuan Lu, Ka Man Li, Jie-Ting Low, Michael Wing-Yan Chan, Howard H.W. Leung, Anthony W.H. Chan, Ka-Fai To, Kevin Yuk-Lap Yip, Yuk Ming Dennis Lo, Joseph Jao-Yiu Sung, Alfred Sze-Lok Cheng

Gut Apr 2023, gutjnl-2022-328364; DOI: 10.1136/gutjnl-2022-328364
Autologous T cell responses to primary human colorectal cancer spheroids are enhanced by ectonucleotidase inhibition
Julie Bonnereau, Tristan Courau, Nicolas Asesio, Delphine Salfati, Fatiha Bouhidel, Hélène Corte, Sarah Hamoudi, Nassim Hammoudi, Julie Lavolé, Justine Vivier-Chicoteau, Victor Chardiny, Leon Maggiori, Mathieu Blery, Romain Remark, Cécile Bonnafous, Pierre Cattan, Antoine Toubert, Purnima Bhat, Matthieu Allez, Thomas Aparicio, Lionel Le Bourhis

Gut Apr 2023, 72 (4) 699-709; DOI: 10.1136/gutjnl-2021-326553
Spatially restricted tumour-associated and host-associated immune drivers correlate with the recurrence sites of pancreatic cancer
Eva Karamitopoulou, Anna Silvia Wenning, Animesh Acharjee, Inti Zlobec, Pauline Aeschbacher, Aurel Perren, Beat Gloor

Gut Feb 2023, gutjnl-2022-329371; DOI: 10.1136/gutjnl-2022-329371
IL-17A-producing CD8⁺ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
Felix Simon Ruben Picard, Veronika Lutz, Anna Brichkina, Felix Neuhaus, Teresa Ruckenbrod, Anna Hupfer, Hartmann Raifer, Matthias Klein, Tobias Bopp, Petra Ina Pfefferle, Rajkumar Savai, Immo Prinz, Ari Waisman, Sonja Moos, Hyun-Dong Chang, Stefan Heinrich, Detlef K Bartsch, Malte Buchholz, Shiv Singh, Mengyu Tu, Lukas Klein, Christian Bauer, Robert Liefke, Andreas Burchert, Ho-Ryun Chung, Philipp Mayer, Thomas M Gress, Matthias Lauth, Matthias Gaida, Magdalena Huber

Gut Feb 2023, gutjnl-2022-327855; DOI: 10.1136/gutjnl-2022-327855
MicroRNA-223 attenuates hepatocarcinogenesis by blocking hypoxia-driven angiogenesis and immunosuppression
Yaojie Fu, Bryan Mackowiak, Dechun Feng, Hongkun Lu, Yukun Guan, Taylor Lehner, Hongna Pan, Xin Wei Wang, Yong He, Bin Gao

Gut Jan 2023, gutjnl-2022-327924; DOI: 10.1136/gutjnl-2022-327924
PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
Li-Gong Lu, Zhi-Ling Zhou, Xu-Yan Wang, Bo-Yuan Liu, Jin-Ying Lu, Shuai Liu, Guang-Bo Zhang, Mei-Xiao Zhan, Yun Chen

Gut Dec 2022, 71 (12) 2551-2560; DOI: 10.1136/gutjnl-2021-326350
Targeting tumour-intrinsic N⁷-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy
Haining Liu, Xuezhen Zeng, Xuxin Ren, Yifan Zhang, Manling Huang, Li Tan, Zihao Dai, Jiaming Lai, Wenxuan Xie, Zebin Chen, Sui Peng, Lixia Xu, Shuling Chen, Shunli Shen, Ming Kuang, Shuibin Lin

Gut Oct 2022, gutjnl-2022-327230; DOI: 10.1136/gutjnl-2022-327230
Cancer as microenvironmental, systemic and environmental diseases: opportunity for transdisciplinary microbiomics science
Kentaro Inamura, Tsuyoshi Hamada, Susan Bullman, Tomotaka Ugai, Shinichi Yachida, Shuji Ogino

Gut Oct 2022, 71 (10) 2107-2122; DOI: 10.1136/gutjnl-2022-327209
Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy
Jumin Huang, Di Liu, Yuwei Wang, Liang Liu, Jian Li, Jing Yuan, Zhihong Jiang, Zebo Jiang, WL Wendy Hsiao, Haizhou Liu, Imran Khan, Ying Xie, Jianlin Wu, Yajia Xie, Yizhong Zhang, Yu Fu, Junyi Liao, Wenjun Wang, Huanling Lai, Axi Shi, Jun Cai, Lianxiang Luo, Runze Li, Xiaojun Yao, Xingxing Fan, Qibiao Wu, Zhongqiu Liu, Peiyu Yan, Jingguang Lu, Mingrong Yang, Lin Wang, Yabing Cao, Hong Wei, Elaine Lai-Han Leung

Gut Apr 2022, 71 (4) 734-745; DOI: 10.1136/gutjnl-2020-321031
Helicobacter pylori infection has a detrimental impact on the efficacy of cancer immunotherapies
Paul Oster, Laurie Vaillant, Erika Riva, Brynn McMillan, Christina Begka, Caroline Truntzer, Corentin Richard, Marine M Leblond, Meriem Messaoudene, Elisavet Machremi, Emeric Limagne, Francois Ghiringhelli, Bertrand Routy, Gregory Verdeil, Dominique Velin

Gut Mar 2022, 71 (3) 457-466; DOI: 10.1136/gutjnl-2020-323392

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