DNA Damage

Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer
Johann Gout, Lukas Perkhofer, Mareen Morawe, Frank Arnold, Michaela Ihle, Stephanie Biber, Sebastian Lange, Elodie Roger, Johann M Kraus, Katja Stifter, Stephan A Hahn, Andrea Zamperone, Thomas Engleitner, Martin Müller, Karolin Walter, Eva Rodriguez-Aznar, Bruno Sainz Jr, Patrick C Hermann, Elisabeth Hessmann, Sebastian Müller, Ninel Azoitei, André Lechel, Stefan Liebau, Martin Wagner, Diane M Simeone, Hans A Kestler, Thomas Seufferlein, Lisa Wiesmüller, Roland Rad, Pierre-Olivier Frappart, Alexander Kleger

Gut Apr 2021, 70 (4) 743-760; DOI: 10.1136/gutjnl-2019-319970
DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
Lukas Perkhofer, Johann Gout, Elodie Roger, Fernando Kude de Almeida, Carolina Baptista Simões, Lisa Wiesmüller, Thomas Seufferlein, Alexander Kleger

Gut Mar 2021, 70 (3) 606-617; DOI: 10.1136/gutjnl-2019-319984
Unified definition of relapse-free survival should be used for evaluating survival benefit in oesophageal adenocarcinoma
Weizheng Li

Gut Jan 2021, 70 (1) 228; DOI: 10.1136/gutjnl-2020-321482
DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia
Vaidehi Krishnan, Debbie Xiu En Lim, Phuong Mai Hoang, Supriya Srivastava, Junichi Matsuo, Kie Kyon Huang, Feng Zhu, Khek Yu Ho, Jimmy Bok Yan So, Christopher Khor, Stephen Tsao, Ming Teh, Kwong Ming Fock, Tiing Leong Ang, Anand D Jeyasekharan, Patrick Tan, Khay-Guan Yeoh, Yoshiaki Ito

Gut Oct 2020, 69 (10) 1738-1749; DOI: 10.1136/gutjnl-2019-319002
USF1 defect drives p53 degradation during Helicobacter pylori infection and accelerates gastric carcinogenesis
Lionel Costa, Sébastien Corre, Valérie Michel, Krysten Le Luel, Julien Fernandes, Jason Ziveri, Gregory Jouvion, Anne Danckaert, Nicolas Mouchet, David Da Silva Barreira, Javier Torres, Margarita Camorlinga, Mario Milco D'Elios, Laurence Fiette, Hilde De Reuse, Marie-Dominique Galibert, Eliette Touati

Gut Sep 2020, 69 (9) 1582-1591; DOI: 10.1136/gutjnl-2019-318640
Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair
Avital Guedj, Yael Volman, Anat Geiger-Maor, Julia Bolik, Neele Schumacher, Sven Künzel, John F Baines, Yuval Nevo, Sharona Elgavish, Eithan Galun, Hagai Amsalem, Dirk Schmidt-Arras, Jacob Rachmilewitz

Gut Jun 2020, 69 (6) 1064-1075; DOI: 10.1136/gutjnl-2019-318491
CDK12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma
Cun Wang, Hui Wang, Cor Lieftink, Aimee du Chatinier, Dongmei Gao, Guangzhi Jin, Haojie Jin, Roderick L Beijersbergen, Wenxin Qin, René Bernards

Gut Apr 2020, 69 (4) 727-736; DOI: 10.1136/gutjnl-2019-318506
Immune activation by DNA damage predicts response to chemotherapy and survival in oesophageal adenocarcinoma
Richard C Turkington, Laura A Knight, Jaine K Blayney, Maria Secrier, Rosalie Douglas, Eileen E Parkes, Eilis K Sutton, Leanne Stevenson, Damian McManus, Sophia Halliday, Andrena M McCavigan, Gemma E Logan, Steven M Walker, Christopher J Steele, Juliane Perner, Jan Bornschein, Shona MacRae, Ahmad Miremadi, Eamon McCarron, Stephen McQuaid, Kenneth Arthur, Jacqueline A James, Martin M Eatock, Robert O’Neill, Fergus Noble, Timothy J Underwood, D Paul Harkin, Manuel Salto-Tellez, Rebecca C Fitzgerald, Richard D Kennedy

Gut Nov 2019, 68 (11) 1918-1927; DOI: 10.1136/gutjnl-2018-317624
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient, hyperdiploid colorectal cancer stem cells
Gwenola Manic, Michele Signore, Antonella Sistigu, Giorgio Russo, Francesca Corradi, Silvia Siteni, Martina Musella, Sara Vitale, Maria Laura De Angelis, Matteo Pallocca, Carla Azzurra Amoreo, Francesca Sperati, Simone Di Franco, Sabina Barresi, Eleonora Policicchio, Gabriele De Luca, Francesca De Nicola, Marcella Mottolese, Ann Zeuner, Maurizio Fanciulli, Giorgio Stassi, Marcello Maugeri-Saccà, Marta Baiocchi, Marco Tartaglia, Ilio Vitale, Ruggero De Maria

Gut May 2018, 67 (5) 903-917; DOI: 10.1136/gutjnl-2016-312623
Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatment
Lisanne S Rigter, Petur Snaebjornsson, Efraim H Rosenberg, Peggy N Atmodimedjo, Berthe M Aleman, Jelle ten Hoeve, Willemina R Geurts-Giele, PALGA group, Thomas W van Ravesteyn, Johan Hoeksel, Gerrit A Meijer, Hein te Riele, Flora E van Leeuwen, Winand N Dinjens, Monique E van Leerdam

Gut Mar 2018, 67 (3) 447-455; DOI: 10.1136/gutjnl-2016-312608

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