IBD basic research

Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation
Margarita Martinez-Medina, Jérémy Denizot, Nicolas Dreux, Frédéric Robin, Elisabeth Billard, Richard Bonnet, Arlette Darfeuille-Michaud, Nicolas Barnich

Gut Jan 2014, 63 (1) 116-124; DOI: 10.1136/gutjnl-2012-304119
Mucosal CXCR4⁺ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation
Michihide Uo, Tadakazu Hisamatsu, Jun Miyoshi, Daiki Kaito, Kazuaki Yoneno, Mina T Kitazume, Maiko Mori, Akira Sugita, Kazutaka Koganei, Katsuyoshi Matsuoka, Takanori Kanai, Toshifumi Hibi

Gut Dec 2013, 62 (12) 1734-1744; DOI: 10.1136/gutjnl-2012-303063
MTG16 contributes to colonic epithelial integrity in experimental colitis
Christopher S Williams, Amber M Bradley, Rupesh Chaturvedi, Kshipra Singh, Maria B Piazuelo, Xi Chen, Elizabeth M McDonough, David A Schwartz, Caroline T Brown, Margaret M Allaman, Lori A Coburn, Sara N Horst, Dawn B Beaulieu, Yash A Choksi, Mary Kay Washington, Amanda D Williams, Melissa A Fisher, Sandra S Zinkel, Richard M Peek, Keith T Wilson, Scott W Hiebert

Gut Oct 2013, 62 (10) 1446-1455; DOI: 10.1136/gutjnl-2011-301439
A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis
Paul J Rutgeerts, Richard N Fedorak, Daan W Hommes, Andreas Sturm, Daniel C Baumgart, Brian Bressler, Stefan Schreiber, John C Mansfield, Marna Williams, Meina Tang, Jennifer Visich, Xiaohui Wei, Mary Keir, Diana Luca, Dimitri Danilenko, Jackson Egen, Sharon O'Byrne

Gut Aug 2013, 62 (8) 1122-1130; DOI: 10.1136/gutjnl-2011-301769
Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells
Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe

Gut Aug 2013, 62 (8) 1142-1152; DOI: 10.1136/gutjnl-2012-302029
The intermediate filament protein, vimentin, is a regulator of NOD2 activity
Craig Stevens, Paul Henderson, Elaine R Nimmo, Dinesh C Soares, Belgin Dogan, Kenneth W Simpson, Jeffrey C Barrett, International Inflammatory Bowel Disease Genetics Consortium, David C Wilson, Jack Satsangi

Gut May 2013, 62 (5) 695-707; DOI: 10.1136/gutjnl-2011-301775
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
Christian Sina, Simone Lipinski, Olga Gavrilova, Konrad Aden, Ateequr Rehman, Andreas Till, Andrea Rittger, Rainer Podschun, Ulf Meyer-Hoffert, Robert Haesler, Emilie Midtling, Katrin Pütsep, Michael A McGuckin, Stefan Schreiber, Paul Saftig, Philip Rosenstiel

Gut Apr 2013, 62 (4) 520-530; DOI: 10.1136/gutjnl-2011-300076
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease
Stefanie Derer, Andreas Till, Robert Haesler, Christian Sina, Nils Grabe, Sascha Jung, Susanna Nikolaus, Tanja Kuehbacher, Joachim Groetzinger, Stefan Rose-John, Philip C Rosenstiel, Stefan Schreiber

Gut Mar 2013, 62 (3) 376-386; DOI: 10.1136/gutjnl-2011-300384
A metagenomic insight into our gut's microbiome
Patricia Lepage, Marion C Leclerc, Marie Joossens, Stanislas Mondot, Hervé M Blottière, Jeroen Raes, Dusko Ehrlich, Joel Doré

Gut Jan 2013, 62 (1) 146-158; DOI: 10.1136/gutjnl-2011-301805
Ectopic lymphoid tissue alters the chemokine gradient, increases lymphocyte retention and exacerbates murine ileitis
Eóin N McNamee, Joanne C Masterson, Paul Jedlicka, Colm B Collins, Ifor R Williams, Jesús Rivera-Nieves

Gut Jan 2013, 62 (1) 53-62; DOI: 10.1136/gutjnl-2011-301272

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