IBD basic research

Mucosal CXCR4⁺ IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation
Michihide Uo, Tadakazu Hisamatsu, Jun Miyoshi, Daiki Kaito, Kazuaki Yoneno, Mina T Kitazume, Maiko Mori, Akira Sugita, Kazutaka Koganei, Katsuyoshi Matsuoka, Takanori Kanai, Toshifumi Hibi

Gut Dec 2013, 62 (12) 1734-1744; DOI: 10.1136/gutjnl-2012-303063
MTG16 contributes to colonic epithelial integrity in experimental colitis
Christopher S Williams, Amber M Bradley, Rupesh Chaturvedi, Kshipra Singh, Maria B Piazuelo, Xi Chen, Elizabeth M McDonough, David A Schwartz, Caroline T Brown, Margaret M Allaman, Lori A Coburn, Sara N Horst, Dawn B Beaulieu, Yash A Choksi, Mary Kay Washington, Amanda D Williams, Melissa A Fisher, Sandra S Zinkel, Richard M Peek, Keith T Wilson, Scott W Hiebert

Gut Oct 2013, 62 (10) 1446-1455; DOI: 10.1136/gutjnl-2011-301439
Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4 memory T cells
Yasuhiro Nemoto, Takanori Kanai, Masahiro Takahara, Shigeru Oshima, Tetsuya Nakamura, Ryuichi Okamoto, Kiichiro Tsuchiya, Mamoru Watanabe

Gut Aug 2013, 62 (8) 1142-1152; DOI: 10.1136/gutjnl-2012-302029
A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis
Paul J Rutgeerts, Richard N Fedorak, Daan W Hommes, Andreas Sturm, Daniel C Baumgart, Brian Bressler, Stefan Schreiber, John C Mansfield, Marna Williams, Meina Tang, Jennifer Visich, Xiaohui Wei, Mary Keir, Diana Luca, Dimitri Danilenko, Jackson Egen, Sharon O'Byrne

Gut Aug 2013, 62 (8) 1122-1130; DOI: 10.1136/gutjnl-2011-301769
The intermediate filament protein, vimentin, is a regulator of NOD2 activity
Craig Stevens, Paul Henderson, Elaine R Nimmo, Dinesh C Soares, Belgin Dogan, Kenneth W Simpson, Jeffrey C Barrett, International Inflammatory Bowel Disease Genetics Consortium, David C Wilson, Jack Satsangi

Gut May 2013, 62 (5) 695-707; DOI: 10.1136/gutjnl-2011-301775
Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
Christian Sina, Simone Lipinski, Olga Gavrilova, Konrad Aden, Ateequr Rehman, Andreas Till, Andrea Rittger, Rainer Podschun, Ulf Meyer-Hoffert, Robert Haesler, Emilie Midtling, Katrin Pütsep, Michael A McGuckin, Stefan Schreiber, Paul Saftig, Philip Rosenstiel

Gut Apr 2013, 62 (4) 520-530; DOI: 10.1136/gutjnl-2011-300076
mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn's disease
Stefanie Derer, Andreas Till, Robert Haesler, Christian Sina, Nils Grabe, Sascha Jung, Susanna Nikolaus, Tanja Kuehbacher, Joachim Groetzinger, Stefan Rose-John, Philip C Rosenstiel, Stefan Schreiber

Gut Mar 2013, 62 (3) 376-386; DOI: 10.1136/gutjnl-2011-300384
Interleukin-13 and transforming growth factor β synergise in the pathogenesis of human intestinal fistulae
Michael Scharl, Sandra Frei, Theresa Pesch, Silvia Kellermeier, Joba Arikkat, Pascal Frei, Michael Fried, Achim Weber, Ekkehard Jehle, Anne Rühl, Gerhard Rogler

Gut Jan 2013, 62 (1) 63-72; DOI: 10.1136/gutjnl-2011-300498
A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts
Simon J Leedham, Pedro Rodenas-Cuadrado, Kimberley Howarth, Annabelle Lewis, Sreelakshmi Mallappa, Stefania Segditsas, Hayley Davis, Rosemary Jeffery, Manuel Rodriguez-Justo, Satish Keshav, Simon P L Travis, Trevor A Graham, James East, Susan Clark, Ian P M Tomlinson

Gut Jan 2013, 62 (1) 83-93; DOI: 10.1136/gutjnl-2011-301601
A metagenomic insight into our gut's microbiome
Patricia Lepage, Marion C Leclerc, Marie Joossens, Stanislas Mondot, Hervé M Blottière, Jeroen Raes, Dusko Ehrlich, Joel Doré

Gut Jan 2013, 62 (1) 146-158; DOI: 10.1136/gutjnl-2011-301805

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