IBD basic research

Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice
Wenlong Lin, Chunmei Ma, Fasheng Su, Yu Jiang, Rongrong Lai, Ting Zhang, Kai Sun, Liping Fan, Zijian Cai, Zhongqi Li, He Huang, Jun Li, Xiaojian Wang

Gut Apr 2017, 66 (4) 597-610; DOI: 10.1136/gutjnl-2015-310096
A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion
Matija Hedl, Clara Abraham

Gut Nov 2016, 65 (11) 1799-1811; DOI: 10.1136/gutjnl-2014-308922
miR-301a promotes intestinal mucosal inflammation through induction of IL-17A and TNF-α in IBD
Chong He, Yan Shi, Ruijin Wu, Mingming Sun, Leilei Fang, Wei Wu, Changqin Liu, Maochun Tang, Zhong Li, Ping Wang, Yingzi Cong, Zhanju Liu

Gut Dec 2016, 65 (12) 1938-1950; DOI: 10.1136/gutjnl-2015-309389
Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD
Egle Kvedaraite, Magda Lourda, Maja Ideström, Puran Chen, Selma Olsson-Åkefeldt, Marianne Forkel, Désirée Gavhed, Ulrik Lindforss, Jenny Mjösberg, Jan-Inge Henter, Mattias Svensson

Gut Oct 2016, 65 (10) 1632-1641; DOI: 10.1136/gutjnl-2014-309014
Dysbiotic gut microbiota causes transmissible Crohn's disease-like ileitis independent of failure in antimicrobial defence
Monika Schaubeck, Thomas Clavel, Jelena Calasan, Ilias Lagkouvardos, Sven Bastiaan Haange, Nico Jehmlich, Marijana Basic, Aline Dupont, Mathias Hornef, Martin von Bergen, André Bleich, Dirk Haller

Gut Feb 2016, 65 (2) 225-237; DOI: 10.1136/gutjnl-2015-309333
Geographical patterns of the standing and active human gut microbiome in health and IBD
Ateequr Rehman, Philipp Rausch, Jun Wang, Jurgita Skieceviciene, Gediminas Kiudelis, Ketan Bhagalia, Deepak Amarapurkar, Limas Kupcinskas, Stefan Schreiber, Philip Rosenstiel, John F Baines, Stephan Ott

Gut Feb 2016, 65 (2) 238-248; DOI: 10.1136/gutjnl-2014-308341
Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice
Hiroo Tanaka, Maki Takechi, Hiroshi Kiyonari, Go Shioi, Atsushi Tamura, Sachiko Tsukita

Gut Oct 2015, 64 (10) 1529-1538; DOI: 10.1136/gutjnl-2014-308419
An intestinal arsonist: pathobiont ignites IBD and flees the scene
Stefan Jellbauer, Manuela Raffatellu

Gut Jul 2014, 63 (7) 1034-1035; DOI: 10.1136/gutjnl-2013-305589
Genomic ATG16L1 risk allele-restricted Paneth cell ER stress in quiescent Crohn's disease
J Jasper Deuring, Gwenny M Fuhler, Sergey R Konstantinov, Maikel P Peppelenbosch, Ernst J Kuipers, Colin de Haar, C Janneke van der Woude

Gut Jul 2014, 63 (7) 1081-1091; DOI: 10.1136/gutjnl-2012-303527
Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitis
Joanne C Masterson, Eóin N McNamee, Sophie A Fillon, Lindsay Hosford, Rachel Harris, Shahan D Fernando, Paul Jedlicka, Ryo Iwamoto, Elizabeth Jacobsen, Cheryl Protheroe, Holger K Eltzschig, Sean P Colgan, Makoto Arita, James J Lee, Glenn T Furuta

Gut Aug 2015, 64 (8) 1236-1247; DOI: 10.1136/gutjnl-2014-306998

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