immune-mediated liver damage

HLA-DPA1*02:01~B1*01:01 is a risk haplotype for primary sclerosing cholangitis mediating activation of NKp44+ NK cells
Britta F Zecher, David Ellinghaus, Sebastian Schloer, Annika Niehrs, Benedetta Padoan, Martin E Baumdick, Yuko Yuki, Maureen P Martin, Dawid Glow, Jennifer Schröder-Schwarz, Jennifer Niersch, Sébastien Brias, Luisa M Müller, Robin Habermann, Paul Kretschmer, Tristan Früh, Janis Dänekas, Malte H Wehmeyer, Tobias Poch, Marcial Sebode, International PSC Study Group (IPSCSG), Eva Ellinghaus, Frauke Degenhardt, Christian Körner, Angelique Hoelzemer, Boris Fehse, Karl J Oldhafer, Udo Schumacher, Guido Sauter, Mary Carrington, Andre Franke, Madeleine J Bunders, Christoph Schramm, Marcus Altfeld

Gut Feb 2024, 73 (2) 325-337; DOI: 10.1136/gutjnl-2023-329524
Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice
Tim Hendrikx, Sonja Lang, Dragana Rajcic, Yanhan Wang, Sara McArdle, Kenneth Kim, Zbigniew Mikulski, Bernd Schnabl

Gut Oct 2023, 72 (10) 1959-1970; DOI: 10.1136/gutjnl-2022-328265
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
Aitor Esparza-Baquer, Ibone Labiano, Omar Sharif, Aloña Agirre-Lizaso, Fiona Oakley, Pedro M Rodrigues, Ekaterina Zhuravleva, Colm J O'Rourke, Elizabeth Hijona, Raul Jimenez-Agüero, Ioana Riaño, Ana Landa, Adelaida La Casta, Marco Y W Zaki, Patricia Munoz-Garrido, Mikel Azkargorta, Felix Elortza, Andrea Vogel, Gernot Schabbauer, Patricia Aspichueta, Jesper B Andersen, Sylvia Knapp, Derek A Mann, Luis Bujanda, Jesus Maria Banales, Maria Jesus Perugorria

Gut Jul 2021, 70 (7) 1345-1361; DOI: 10.1136/gutjnl-2019-319227
Non-parenchymal TREM-2 protects the liver from immune-mediated hepatocellular damage
Maria J Perugorria, Aitor Esparza-Baquer, Fiona Oakley, Ibone Labiano, Ana Korosec, Alexander Jais, Jelena Mann, Dina Tiniakos, Alvaro Santos-Laso, Ander Arbelaiz, Riem Gawish, Ana Sampedro, Antonio Fontanellas, Elizabeth Hijona, Raul Jimenez-Agüero, Harald Esterbauer, Dagmar Stoiber, Luis Bujanda, Jesus María Banales, Sylvia Knapp, Omar Sharif, Derek A Mann

Gut Mar 2019, 68 (3) 533-546; DOI: 10.1136/gutjnl-2017-314107
Vascular adhesion protein-1 is elevated in primary sclerosing cholangitis, is predictive of clinical outcome and facilitates recruitment of gut-tropic lymphocytes to liver in a substrate-dependent manner
Palak J Trivedi, Joseph Tickle, Mette Nåmdal Vesterhus, Peter J Eddowes, Tony Bruns, Jani Vainio, Richard Parker, David Smith, Evaggelia Liaskou, Liv Wenche Thorbjørnsen, Gideon M Hirschfield, Kaisa Auvinen, Stefan G Hubscher, Marko Salmi, David H Adams, Chris J Weston

Gut Jun 2018, 67 (6) 1135-1145; DOI: 10.1136/gutjnl-2016-312354
Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors
Verena Wieser, Timon E Adolph, Barbara Enrich, Athan Kuliopulos, Arthur Kaser, Herbert Tilg, Nicole C Kaneider

Gut May 2017, 66 (5) 930-938; DOI: 10.1136/gutjnl-2015-310344
Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer
Carlo Schneider, Andreas Teufel, Tetyana Yevsa, Frank Staib, Anja Hohmeyer, Gudrun Walenda, Henning W Zimmermann, Mihael Vucur, Sebastian Huss, Nikolaus Gassler, Hermann E Wasmuth, Sergio A Lira, Lars Zender, Tom Luedde, Christian Trautwein, Frank Tacke

Gut Dec 2012, 61 (12) 1733-1743; DOI: 10.1136/gutjnl-2011-301116
Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection
Choong Tat Keng, Ching Wooen Sze, Dahai Zheng, Zhiqiang Zheng, Kylie Su Mei Yong, Shu Qi Tan, Jessica Jie Ying Ong, Sue Yee Tan, Eva Loh, Megha Haridas Upadya, Chik Hong Kuick, Hak Hotta, Seng Gee Lim, Thiam Chye Tan, Kenneth T E Chang, Wanjin Hong, Jianzhu Chen, Yee-Joo Tan, Qingfeng Chen

Gut Oct 2016, 65 (10) 1744-1753; DOI: 10.1136/gutjnl-2014-307856
Spleen size for the prediction of clinical outcome in patients with primary sclerosing cholangitis
Hanno Ehlken, Raluca Wroblewski, Christophe Corpechot, Lionel Arrivé, Susanne Lezius, Johannes Hartl, Ulrike W Denzer, Ansgar W Lohse, Olivier Chazouilleres, Christoph Schramm

Gut Jul 2016, 65 (7) 1230-1232; DOI: 10.1136/gutjnl-2016-311452
Expression of B and T lymphocyte attenuator (BTLA) in macrophages contributes to the fulminant hepatitis caused by murine hepatitis virus strain-3
Chengying Yang, Yongwen Chen, Guoning Guo, Hong Li, Dayan Cao, Huan Xu, Sheng Guo, Lei Fei, Weiming Yan, Qing Ning, Lixin Zheng, Yuzhang Wu

Gut Aug 2013, 62 (8) 1204-1213; DOI: 10.1136/gutjnl-2012-302239

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