molecular oncology

British Society of Gastroenterology guidelines for the management of hepatocellular carcinoma in adults
Abid Suddle, Helen Reeves, Richard Hubner, Aileen Marshall, Ian Rowe, Dina Tiniakos, Stefan Hubscher, Mark Callaway, Dinesh Sharma, Teik Choon See, Maria Hawkins, Suzanne Ford-Dunn, Sarah Selemani, Tim Meyer

Gut Apr 2024, gutjnl-2023-331695; DOI: 10.1136/gutjnl-2023-331695
Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer
Feifei Zhang, Varun Sahu, Ke Peng, Yichen Wang, Tianxia Li, Pratyusha Bala, Daulet Aitymbayev, Pranshu Sahgal, Antje Schaefer, Channing J Der, Sandra Ryeom, Sam Yoon, Nilay Sethi, Adam J Bass, Haisheng Zhang

Gut Apr 2024, gutjnl-2023-329686; DOI: 10.1136/gutjnl-2023-329686
High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT
Lang Bu, Zhengkun Zhang, Jianwen Chen, Yizeng Fan, Jinhe Guo, Yaqing Su, Huan Wang, Xiaomei Zhang, Xueji Wu, Qiwei Jiang, Bing Gao, Lei Wang, Kunpeng Hu, Xiang Zhang, Wei Xie, Wenyi Wei, Ming Kuang, Jianping Guo

Gut Jan 2024, gutjnl-2023-330826; DOI: 10.1136/gutjnl-2023-330826
EGFR amplification and outcome in a randomised phase III trial of chemotherapy alone or chemotherapy plus panitumumab for advanced gastro-oesophageal cancers
Elizabeth C Smyth, Georgios Vlachogiannis, Somaieh Hedayat, Alice Harbery, Sanna Hulkki-Wilson, Massimiliano Salati, Kyriakos Kouvelakis, Javier Fernandez-Mateos, George D Cresswell, Elisa Fontana, Therese Seidlitz, Clare Peckitt, Jens C Hahne, Andrea Lampis, Ruwaida Begum, David Watkins, Sheela Rao, Naureen Starling, Tom Waddell, Alicia Okines, Tom Crosby, Was Mansoor, Jonathan Wadsley, Gary Middleton, Matteo Fassan, Andrew Wotherspoon, Chiara Braconi, Ian Chau, Igor Vivanco, Andrea Sottoriva, Daniel E Stange, David Cunningham, Nicola Valeri

Gut Sep 2021, 70 (9) 1632-1641; DOI: 10.1136/gutjnl-2020-322658
Treatment of advanced gastroenteropancreatic neuroendocrine neoplasia, are we on the way to personalised medicine?
Anja Rinke, Christoph J Auernhammer, Lisa Bodei, Mark Kidd, Sebastian Krug, Rita Lawlor, Ilaria Marinoni, Aurel Perren, Aldo Scarpa, Halfdan Sorbye, Marianne Ellen Pavel, Matthias M Weber, Irvin Modlin, Thomas M Gress

Gut Sep 2021, 70 (9) 1768-1781; DOI: 10.1136/gutjnl-2020-321300
Integrative multiomics enhancer activity profiling identifies therapeutic vulnerabilities in cholangiocarcinoma of different etiologies
Jing Han Hong, Chern Han Yong, Hong Lee Heng, Jason Yongsheng Chan, Mai Chan Lau, Jianfeng Chen, Jing Yi Lee, Abner Herbert Lim, Zhimei Li, Peiyong Guan, Pek Lim Chu, Arnoud Boot, Sheng Rong Ng, Xiaosai Yao, Felicia Yu Ting Wee, Jeffrey Chun Tatt Lim, Wei Liu, Peili Wang, Rong Xiao, Xian Zeng, Yichen Sun, Joanna Koh, Xiu Yi Kwek, Cedric Chuan Young Ng, Poramate Klanrit, Yaojun Zhang, Jiaming Lai, David Wai Meng Tai, Chawalit Pairojkul, Simona Dima, Irinel Popescu, Sen-Yung Hsieh, Ming-Chin Yu, Joe Yeong, Sarinya Kongpetch, Apinya Jusakul, Watcharin Loilome, Patrick Tan, Jing Tan, Bin Tean Teh

Gut Nov 2023, gutjnl-2023-330483; DOI: 10.1136/gutjnl-2023-330483
Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification
Carla Montironi, Florian Castet, Philipp K Haber, Roser Pinyol, Miguel Torres-Martin, Laura Torrens, Agavni Mesropian, Huan Wang, Marc Puigvehi, Miho Maeda, Wei Qiang Leow, Elizabeth Harrod, Patricia Taik, Jigjidsuren Chinburen, Erdenebileg Taivanbaatar, Enkhbold Chinbold, Manel Solé Arqués, Michael Donovan, Swan Thung, Jaclyn Neely, Vincenzo Mazzaferro, Jeffrey Anderson, Sasan Roayaie, Myron Schwartz, Augusto Villanueva, Scott L Friedman, Andrew Uzilov, Daniela Sia, Josep M Llovet

Gut Jan 2023, 72 (1) 129-140; DOI: 10.1136/gutjnl-2021-325918
S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos
Xia Wang, Hongyang Huang, Karen Man-Fong Sze, Jin Wang, Lu Tian, Jingyi Lu, Yu-Man Tsui, Hoi Tang Ma, Eva Lee, Ao Chen, Joyce Lee, Ying Wang, Judy Wai Ping Yam, Tan-To Cheung, Xinyuan Guan, Irene Oi-Lin Ng

Gut Jul 2023, 72 (7) 1370-1384; DOI: 10.1136/gutjnl-2022-327998
Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen

Gut Jun 2023, 72 (6) 1174-1185; DOI: 10.1136/gutjnl-2022-328154
Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma
Marta Alonso-Nocelo, Laura Ruiz-Cañas, Patricia Sancho, Kıvanç Görgülü, Sonia Alcalá, Coral Pedrero, Mireia Vallespinos, Juan Carlos López-Gil, Marina Ochando, Elena García-García, Sara Maria David Trabulo, Paola Martinelli, Patricia Sánchez-Tomero, Carmen Sánchez-Palomo, Patricia Gonzalez-Santamaría, Lourdes Yuste, Sonja Maria Wörmann, Derya Kabacaoğlu, Julie Earl, Alberto Martin, Fernando Salvador, Sandra Valle, Laura Martin-Hijano, Alfredo Carrato, Mert Erkan, Laura García-Bermejo, Patrick C Hermann, Hana Algül, Gema Moreno-Bueno, Christopher Heeschen, Francisco Portillo, Amparo Cano, Bruno Sainz

Gut Feb 2023, 72 (2) 345-359; DOI: 10.1136/gutjnl-2021-325564

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