Research Articles
Gi Absorption of β-Lactam Antibiotics III: Kinetic Evidence for In Situ Absorption of Ionized Species of Monobasic Penicillins and Cefazolin from the Rat Small Intestine and Structure-Absorption Rate Relationships

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Abstract

Absorption rates of monobasic β-lactam antibiotics were measured as a function of lumen solution pH between 4 and 9 by utilizing the rat intestinal recirculating method in situ. Between pH 6.5 and 9, the absorption rate constants of ionized antibiotics were almost identical; but, at pH 4, the unionized species were highly absorbed, depending on their lipophilicity through the GI membrane lipoidal barrier. The structure-absorption rate relationship was established with the unstirred layer model.

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