Regular ArticleStructural Heterogeneity of Caucasian N-Acetyltransferase at the NAT1 Gene Locus
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Genetic polymorphism of NAT1 in local Pakistani population
2021, Gene ReportsCitation Excerpt :Many studies have demonstrated that NAT1 genetic polymorphism is related to a predisposition to numerous cancers from heterocyclic amine carcinogens and arylamines (Doll and Hein, 2002). The NAT1 gene polymorphism was firstly described two decades ago (Vatsis and Weber, 1993), and the identified alleles in human populations were almost 26; NAT1*3, NAT1*4, NAT1*10 and NAT1*11 being the most prevalent alleles reported. A single mutation (SNP) or a combination of multiple nucleotide substitutions and insertions/deletions are responsible for the allelic variants of NAT1.
Arylamine N-Acetyltransferases
2018, Comprehensive Toxicology: Third EditionStructural and functional effects of nucleotide variation on the human TB drug metabolizing enzyme arylamine N-acetyltransferase 1
2017, Journal of Molecular Graphics and ModellingCitation Excerpt :Since human NAT1 plays a vital role in detoxification and potential metabolic activation of xenobiotic compounds, it is important in clinical pharmacology and toxicology. Previous research has shown non-synonymous single nucleotide polymorphisms (nsSNPs) in the genomic DNA sequence of human NAT1 that imply changes in its amino acid sequence [10–14]. This has the potential to destabilize the enzyme structure and negatively affect the function of the NAT1 enzyme.
Arylamine N-acetyltransferases
2010, Comprehensive Toxicology, Second EditionAntioxidant enzymes, presbycusis, and ethnic variability
2010, Otolaryngology - Head and Neck SurgeryCitation Excerpt :The resulting 369-bp (primers set A) and 547-bp (primers set B) PCR products were subjected to RFLP analysis and the primer sequences provided as requested. The presence or absence of the T341C nucleotide substitution was detected by use of the allele-specific PCR method described by Vatsis and Weber.14 G191A, C282T, C341T, C480T, G590A, and G857 substitutions were confirmed by direct sequencing on an automated sequencer (ABI 3100).
The Role of Drug Metabolism in Toxicity
2022, DRUG METABOLISM HANDBOOK: CONCEPTS AND APPLICATIONS IN CANCER RESEARCH