Biochemical and Biophysical Research Communications
Regular ArticleSignificance of Vascular Endothelial Growth Factor/Vascular Permeability Factor for Solid Tumor Growth, and Its Inhibition by the Antibody
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Age-Related Macular Degeneration: An Overview
2014, Handbook of Nutrition, Diet and the EyeRefractive errors and age-related macular degeneration: A systematic review and meta-analysis
2013, OphthalmologyCitation Excerpt :Vascular endothelial growth factor plays a key role in AMD pathophysiology.5 Vascular endothelial growth factor is a key regulator of angiogenesis, and withdrawal or interference with its function leads to cessation of vascular growth and neovascular regression.31 Recent findings indicated that the intraocular concentration of VEGF decreased significantly with increasing myopia and increasing AL,32 which may explain why myopic eyes have a lower prevalence of AMD because decreasing intraocular concentration of VEGF could lower the risk of AMD.
Age-related macular degeneration
2012, The LancetCitation Excerpt :More recently, attention has been focused on the function of VEGF in light of its role as a therapeutic target.39 VEGF is a key regulator of angiogenesis, and withdrawal or interference with its function leads to cessation of vascular growth and neovascular regression.40 VEGF expression has been shown in experimental choroidal neovascularisation, and shown to induce choroidal neovascularisation growth in animals.
Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome
2009, Cancer LettersCitation Excerpt :Vascular endothelial growth factors (VEGF) and its receptors are the key players in angiogensis. By binding to its receptors, VEGFR-1 and VEGFR-2, this proangiogenic factor can trigger a series of downstream signaling cascades and facilitate angiogenesis [36,37]. It has been found that VEGF and VEGFRs were overexpressed in ovarian carcinoma when compared with the benign ovarian tumours and normal OSE cells [32].
The role of vascular endothelial growth factor and other endogenous interplayers in age-related macular degeneration
2008, Progress in Retinal and Eye ResearchVascular Endothelial Growth Factor Immunostaining Correlates with Postoperative Relapse and Survival in Non-Small Cell Lung Cancer
2007, Archives of Medical Research