Regular ArticleMechanical Stress Is Required for High-Level Expression of Connective Tissue Growth Factor☆
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2019, Experimental Cell ResearchCitation Excerpt :In the context of a myofibroblast-derived ECM that provides ligands for αv integrins and in dependence of FAK activation, LPA also stimulates the expression of CCN2 (formerly known as connective tissue growth factor-CTGF) [166]. CCN2 expression and incorporation into the ECM are further induced by active TGF-β and mechanical stress [167,168]. CCN2 is a matricellular protein (not a growth factor) and has been suggested to modulate myofibroblast fate through several mechanisms that are associated with its multi-domain structure.
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2015, Progress in Molecular Biology and Translational ScienceOsteocyte function under compressive mechanical force
2014, Japanese Dental Science ReviewCitation Excerpt :Exposure of human mesangial cells to hydrostatic pressure for 48 h markedly increased CCN2 protein levels [125]. CCN2 mRNA expression decreased to 25% in 24 h after the load was removed in human lung fibroblasts [126], while it decreased to about 13% in vascular endothelial cells after fluid shear stress for 6 h [127]. Wong et al. [128] compared the effects of tensile strain and cyclic hydrostatic pressure on CCN2 expression in primary chondrocytes.
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This study was supported by the Swiss National Science Foundation (Grants 31-50571.97 and 31-61296.00).
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