Regular ArticleUp-Regulation of TNFα mRNA in the Rat Spleen Following Induction of Acute Pancreatitis
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A New Role for the Spleen: Aggravation of the Systemic Inflammatory Response in Rats with Severe Acute Pancreatitis
2019, American Journal of PathologyHypothermia slows sequential and parallel steps initiated during caerulein pancreatitis
2014, PancreatologyCitation Excerpt :Despite several pharmacologic trials conducted to improve outcomes in AP patients using serine protease inhibitors [9–18], there is no conclusive data from such studies showing benefit. Similarly, while cytokines like TNF-α are increased in AP [19–23] there have been conflicting case reports of the effect of anti-TNF therapy on the course of AP [24–26]. Hypothermia has been shown to prevent inflammatory mediator generation and cell death in various systems.
The Inflammatory Cascade in Acute Pancreatitis: Relevance to Clinical Disease
2007, Surgical Clinics of North AmericaCitation Excerpt :The number of agents used in experimental animals to modify, ameliorate, or abort AP is too large to enumerate. The authors' laboratory embarked on a series of experiments to modify the disease using TNF α blockers [79,93–95]. These observations were reproduced by others [64,96], although TNF was not found routinely in plasma samples of patients who had AP [97].
Cytokines and acute pancreatitis
1999, Bailliere's Best Practice in Clinical GastroenterologyOverexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats
1998, Biochemical and Biophysical Research Communications