Regular ArticleModulation of Intestinal Permeability: An Innovative Method of Oral Drug Delivery for the Treatment of Inherited and Acquired Human Diseases☆
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2018, International Journal of Biological MacromoleculesCitation Excerpt :The immunological significance of these uptake mechanisms has yet to be determined, but there is some evidence that they might facilitate the sampling of luminal immune complexes by the mucosal immune system [10]. Though, oral vaccines available in the market against poliomyelitis, typhoid, cholera, adenovirus and live reassortant rotavirus, but still unsatisfactory progress has been observed towards the development of oral vaccines due to drug instability in the GI track and low uptake at mucus layer [11,12]. Approximately, 25 licensed vaccines recommended for humans are available with the non-mucosal route of administration like subcutaneous or intramuscular inoculation which helps to elicit only systemic immune response not the mucosal immunity.
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Supported by the National Institute of Health Grants DK-48373 and AI-35740.