Regular ArticleCadmium Absorption and Its Relationship to Divalent Metal Transporter-1 in the Pregnant Rat☆
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2019, ChemosphereCitation Excerpt :Finally, increased Cd concentration was found in organs of pups whose mothers were exposed during gestation only (Jacquillet et al., 2007; Wang et al., 2016a) or gestation and lactation (Bekheet, 2011; Chemek et al., 2016). Cd exposure of pregnant females is of great concern because intestinal absorption is thought to be increased during this period in humans (Nishijo et al., 2004), but also in rodents (Leazer, 2002), leading to a higher amount of Cd entering the blood stream and possibly contaminating the fetus (Nishijo et al., 2004). The issue of progeny sensitivity to impairment of glucose homeostasis induced by contaminated mothers is important to tackle because, among the dramatically increased number of worldwide type II diabetes, a growing proportion involves young subjects.
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Presented as a poster at the Society of Toxicology Meeting, Nashville, TN, March 17–21, 2002.
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Present address: Nuclear Receptor Functional Analysis, Department of High Throughput Biology, GlaxoSmithKline, Research Triangle Park, NC 27709-3398
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To whom all correspondence should be addressed. Fax (913) 588-7501; E-mail: [email protected]